Faculties of University Bonn: Search
Now showing items 131-140 of 440
The role of cGMP/PKG1 signaling in osteogenic differentiation
(2022-02-25)
Nitric oxide has important effects on bone cell function. NO stimulates cGMP synthesis, activation of protein kinase G (PKGs) and improves proliferation, differentiation, and survival of bone forming cells. In bone resorbing ......
Investigations on Marine Natural Products from Indo-Pacific Nudibranchia (Mollusca: Gastropoda): Chemoecology, Medicinal Potential & Toxin Resistance
(2022-03-22)
This thesis focusses on the investigation of marine natural products (MNPs) from nudibranchs of the Central Indo-Pacific Ocean and their food sources. MNPs are important lead structures in the drug discovery process, as ......
Computer Assisted Diagnosis in PET/CT: Machine Learning for Prognosis in Oncological Patients
(2022-03-29)
Artificial intelligence (AI) has revolutionised problem solving in a wide range of industrial as well as research domains. Particularly, computer-aided diagnosis (CAD) and clinical decision support systems (CDSSs) as ...
Immunphänotypisierung von Patienten im Rahmen von Operationen an der Herz-Lungen-Maschine hinsichtlich der Entwicklung eines systemisch inflammatorischen Response-Syndroms
(2022-03-14)
Obwohl man schon lange weiß, dass kardiochirurgische Operationen die Entstehung eines SIRS (Systemisch inflammatorisches Response-Syndrom) triggern, ist noch wenig darüber bekannt, warum trotz scheinbar gleicher Bedingungen ...
Untersuchung des Immunreaktivitätsprofils von Müller-Zellen für Nestin, CD44, Kollagen IX und GFAP in fetalen und kindlichen Augen
(2022-03-18)
Ziel dieser Arbeit war es, die Rolle von Müller-Zellen in der Entwicklung der Netzhaut zu untersuchen. Hierfür wurden 39 fetale Augen der 11. bis 38. Schwangerschaftswoche sowie sechs Augen von Säuglingen im Alter von einem ...
Vorkommen Antibiotika-resistenter Bakterien in der aquatischen Umwelt: Zusammenhänge zu dem Vorkommen antibiotisch wirkender Substanzen
(2022-01-05)
Ein Anstieg der Resistenzen bei gleichzeitiger Stagnation hinsichtlich der Ent-wicklung neuer Antibiotika ist vor allem für Infektionen mit Gram-negativen Bakte-rien kritisch. Die WHO spezifizierte bereits 2014 ...
Sequential and coupled inversion of time-lapse borehole GPR measurements for vadose zone model parameterization
(2022-01-31)
A profound understanding of the infiltration dynamics into the vadose zone is crucial to our capacity to link surface and subsurface processes for the description of the hydrologic cycle. A key to establish reliable models ...
Sustainability performance of organic and conventional farming systems in Kenya: Murang'a, Kirinyaga and Machakos Counties
(2022-03-17)
The concept of sustainable farming systems focuses on the need to develop techniques and practices that have positive effects on social outcomes, the environment, and food productivity. In Africa, there are limited empirical ...
Design, synthesis and pharmacological evaluation of nucleotidic and non-nucleotidic inhibitors and probes for the ecto-5'-nucleotidase (CD73)
(2022-03-22)
Ecto-5'-nucleotidase (CD73) plays a central role in the metabolic breakdown of extracellular AMP. The enzyme is attached to the cell membrane by a glycosylphosphatidylinositol anchor, but can also be released by shedding, ...
Developing an integrated value-based institutional framework for analyzing nexus governance challenges: the case study of Germany
(2022-04-04)
Global megatrends, such as the impacts of climate change and global population growth, require an integrated and comprehensive management of natural resources that accounts for the various interrelations that exist between ...