Fakultäten der Universität Bonn: Suche
Anzeige der Dokumente 301-310 von 440
Diagnostische, prognostische und therapeutische Bedeutung der Tumormutationslandschaft und des umgebenden Tumormikromilieus im duktalen Adenokarzinom des Pankreas
(2022-06-07)
Das duktale Adenokarzinom des Pankreas (PDAC) hat unter allen Tumorerkrankungen eine der schlechtesten Überlebensraten und weist eine steigende Inzidenz auf. Die einzige kurative Möglichkeit besteht in der kompletten ...
Einfluss der zellspezifischen Deletion des miR-17~92-Clusters auf die Entwicklung des Kleinhirns
(2022-06-28)
Seit der Entdeckung der ersten micro-Ribonukleinsäure (miRNA/miR) wurde intensiv an der Funktion von miRNAs bei der Entwicklung des Kleinhirns geforscht. Dennoch sind die Mechanismen, über die miRNAs die beteiligten ...
Coloured topological operads and moduli spaces of surfaces with multiple boundary curves
(2022-07-07)
While it is a classical result that the collection of moduli spaces of surfaces with a single boundary curve is an E2-algebra (more precisely: it admits an action of the little 2-cubes operad ......
Targeting aberrant dendritic integration to treat cognitive comorbidities of epilepsy
(2022-07-07)
Memory deficits are one of the most debilitating and common symptoms of temporal lobe epilepsy. However, so far, little is known about mechanisms underlying cognitive deficits and how pharmacologically target them. In most ...
RIG-I agonists as effective anti-viral prophylaxis and treatment in a mouse model of severe SARS-CoV-2 infection
(2022-07-08)
The recent outbreak of the COVID-19 pandemic highlights the need for novel prophylactic and therapeutic countermeasures against newly emerging viruses. Innate immune receptor agonists are considered to be a promising new ...
Hybridverbindungen aus dem Superagonisten Iperoxo und konventionellen inversen Agonisten zeigen Partialagonismus am muskarinischen Acetylcholin-Rezeptor M2 in CHO-Zellen
(2022-07-13)
Der muskarinische Acetylcholin-Rezeptor vom Subtyp M2 dient seit langem als maßgebliches Modellsystem auf dem Gebiet der pharmakologischen Forschung an G-Protein-gekoppelten Rezeptoren (GPCR), weil er über jeweils ...
Essays in Applied Microeconomics
(2022-06-28)
This thesis consists of four independent research papers. Chapter 1 analyzes the impact of consumer myopia on competition and firm behavior. In our model, firms repeatedly sell a primary good and a respective add-on. In ...
Mass Spectrometric Profiling of Lysosomal Protein Interactions, Structures, and Half-lives via Cross-Linking and Pulse Stable Isotope Labeling
(2022-07-08)
In mammalian cells, the lysosome is the central organelle for the degradation of macromolecules and recycling of their building blocks. Mutations in almost every known lysosomal hydrolase lead to a group of rare but ...
How to Conduct Security Studies with Software Developers
(2022-07-13)
As our everyday life depends on software and its security, studies with software developers become ever more important. Motivated by multiple security breaches caused by issues during software development, more studies ...
Neural Network Growth, Structure and Dynamics
(2022-07-13)
The evolutionary emergence of the nervous system provided individual organisms with a substrate for the development of complex behaviors and fast adaptations to dynamic environments. One of the main ways a nervous system ...