Faculties of University Bonn: Search
Now showing items 221-230 of 231
The chromatin organizer Satb1 regulates the differentiation into CD4+ TH subsets and is essential for the development of TH17 cells
(2021-06-04)
CD4+ T cells play a critical role in host defense and tissue homeostasis. Upon encountering their specific antigen, naive CD4+ T cells can differentiate into the effector T helper (TH) subsets ...
Das Cyclodepsipeptid FR900359: Ein Insektizid mit neuem Wirkmechanismus aus Cand. Burkholderia crenata und Chromobacterium vaccinii
(2024-01-16)
Sekundärmetabolite (SM) sind für ihr breites Spektrum an Bioaktivitäten bekannt und daher eine wichtige Quelle für neue Arzneimittelkandidaten. Neben ihrer Relevanz für die Therapie von Erkrankungen sind SM und ihre ......
The cyclic depsipeptide FR900359: An insecticide with a novel mode of action from Cand. Burkholderia crenata and Chromobacterium vaccinii
Secondary metabolites (SM) are known for their broad spectrum ......
The cyclic depsipeptide FR900359: An insecticide with a novel mode of action from Cand. Burkholderia crenata and Chromobacterium vaccinii
Secondary metabolites (SM) are known for their broad spectrum ......
Physical activity and fitness for healthy ageing
(2024-02-19)
The proportion of individuals suffering from age-associated noncommunicable diseases is expected to rise rapidly in the next decades. To maintain health, well-being and socioeconomic stability in an ageing society, identifying ...
Analysis of the physiological response of perivascular adipose tissue during cold exposure
(2023-02-22)
Aortic valve disease (AVD) is common for people over 65 and its severity increases with age. Aortic aneurysm (AA) is the tenth cause of death for men above 55. Its prevalence was estimated to be up to 8.9% for men and up ...
Converting the elusive G protein-coupled adenosine A3 receptor into a highly-stable, well-characterized receptor model for structural studies
(2023-03-06)
The G protein-coupled adenosine A3 receptor (A3AR) is widely expressed in the human body, with the highest expression levels found in lung and liver. The receptor is involved in a number of pathological processes, e.g., ...
Einfluss der Cyclin-abhängigen Kinase 5 auf die Expression des Programmed Cell Death Ligand 1 in murinen Pankreaskarzinomen im Vergleich verschiedener Analysemethoden
(2023-03-23)
Einleitung: Programmed Cell Death Ligand 1 (PD-L1) ist ein immuninhibitorisches Molekül, das für gewöhnlich von bestimmten Immunzellen oder dendritischen Zellen exprimiert wird. Auch verschiedene Tumoren ...
Investigations on structure and biosynthesis of ribosomal peptide natural products involved in a tripartite mutualistic interaction
(2024-04-16)
(noch nicht zugänglich / not yet accessible)
Neuroanatomie und Funktionsmorphologie Peripherer Rezeptorneurone mit Direkten Projektionen in das Protocerebrum des Insektengehirns
(2023-04-20)
Zur Wahrnehmung unterschiedlicher thermischer Reize hat sich bei Insekten eine Reihe von Thermorezeptoren entwickelt. Der pyrophile („feuerliebend“) „Australische Feuerkäfer“ (Merimna atrata) besitzt paarige Infrarot-(IR)-Organe ......
The yeast prion domain Sup35 NM models features of human neurodegenerative diseases in vivo
(2024-05-21)
In neurodegenerative diseases, such as prion diseases and Alzheimer’s disease, disease- associated proteins misfold and form amyloid deposits that progressively invade the CNS, leading to severe neurodegeneration. Accumulating ...
G protein-coupled receptors mobilize intracellular calcium via the Gs-βγ-PLCβ module
(2024-05-22)
(noch nicht zugänglich / not yet accessible)