Faculties of University Bonn: Search
Now showing items 7761-7770 of 7807
Dynamic Normativity: Necessary and Sufficient Conditions for Value Alignment
(2024-06-11)
The critical inquiry pervading the realm of Philosophy, and perhaps extending its influence across all Humanities disciplines, revolves around the intricacies of morality and normativity. Surprisingly, in recent years, ...
Analysis of the physiological response of perivascular adipose tissue during cold exposure
(2023-02-22)
Aortic valve disease (AVD) is common for people over 65 and its severity increases with age. Aortic aneurysm (AA) is the tenth cause of death for men above 55. Its prevalence was estimated to be up to 8.9% for men and up ...
The aqueous corrosion of borosilicate glasses studied in operando by in situ fluid-cell Raman spectroscopy
(2023-01-30)
Die Eigenschaften von Gläsern hängen vor allem von deren chemischen Zusammensetzung ab und sind aufgrund der großen Zusammensetzungsvielfalt sehr variabel, was eine Vielzahl von Anwendungsmöglichkeiten eröffnet.
Urban Flood Resilience: From Benchmarking Resilience to Accelerating Transformation Using Crowdsourcing Data
(2023-02-23)
This thesis represents a significant contribution to the field of disaster resilience in the context of flood hazards in Iran and Germany. In the face of increasingly unpredictable climate-related extreme events, it is ...
Assays and ligands for underexplored membrane proteins with potential as future drug targets
(2023-05-30)
In this study, pharmacological assays were established and employed to identify and characterize compounds regarding their potential as tool compounds, lead structures, and drug candidates for three underexplored potential ...
Effect of deoxyribonuclease-deficiency on myeloid cells under homeostatic and inflammatory conditions
(2022-12-27)
In healthy and diseased individuals, endogenous nucleic acids are present in various forms and need to be processed and cleared. Failed clearance of DNA is associated with an autoimmune disease termed systemic lupus ...
Einfluss der Cyclin-abhängigen Kinase 5 auf die Expression des Programmed Cell Death Ligand 1 in murinen Pankreaskarzinomen im Vergleich verschiedener Analysemethoden
(2023-03-23)
Einleitung: Programmed Cell Death Ligand 1 (PD-L1) ist ein immuninhibitorisches Molekül, das für gewöhnlich von bestimmten Immunzellen oder dendritischen Zellen exprimiert wird. Auch verschiedene Tumoren ...
Platelets shape the immune response of primary human monocytes
(2023-01-13)
Monocytes are circulating immune cells essential to host defense, orchestrating immune responses through the secretion of immunomodulatory mediators. While exuberant monocyte-driven immune responses have life-threatening ...
Charakterisierung der Neddylierung von Cofilin1: Einfluss auf die neuronale Entwicklung
(2022-12-22)
Nachdem lange davon ausgegangen wurde, dass die posttranslationale Modifikation durch Nedd8 nur bestimmte Culline und den Zellzyklus reguliert, sind in den vergangenen Jahren weitere neddylierte Proteine gefunden worden, ...
Mass spectrometric analysis of short-lived intermediates and ancient fossils
(2021-06-14)
The first part of this thesis focuses on mechanistic studies of two L-proline catalyzed reactions with electrospray ionization mass spectrometry. The second part describes mass spectrometric analyses of fossils, dinosaur ...