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The role of the CC chemokine CCL17 in a mouse model of Alzheimer’s disease
(2013-07-25)
In Alzheimer's disease (AD), inflammatory processes are critically involved by cells releasing neurotoxic or neurotrophic factors influencing survival of neurons and synapses, and thereby cognitive behavior. Several ...
Loss of Inhibitory CD33 Signaling Results in Increased Microglial Activation
(2021-06-23)
CD33 is expressed on immune cells of myeloid origin, such as macrophages and microglia. Upon activation, CD33 recruits and activates protein tyrosine phosphatases, which results in attenuation of the activatory signaling ...
The role of the chemokine receptor CXCR3 in mouse models for IL-12-driven CNS-inflammation and Morbus Alzheimer-like neurodegeneration
(2013-01-31)
The chemokine receptor CXCR3 and its corresponding ligands CXCL9, CXCL10 and CXCL11 are well known to be involved in the trafficking and migration of activated CD4+ Th1 T cells, CD8+ T cells and NK ......
Die Rolle des CXCR3 Rezeptors in Mausmodellen für IL-12 induzierter Neuroinflammation und Alzheimer-ähnlicher Neurodegeneration
Im Rahmen von Entzündungsreaktionen sind der Chemokinrezeptor CXCR3 und ......
Die Rolle des CXCR3 Rezeptors in Mausmodellen für IL-12 induzierter Neuroinflammation und Alzheimer-ähnlicher Neurodegeneration
Im Rahmen von Entzündungsreaktionen sind der Chemokinrezeptor CXCR3 und ......
The mind's ratio: How the balance between ω-6 and ω-3 fatty acids affects the risk of late-life dementia
(2022-02-03)
Dementia health care costs are rapidly rising due to the increasing number of people with dementia worldwide that is expected to increase to 66 million by 2030 and 115 million by 2050 (Prince et al., 2013). Intensive ......
Ectopic expression of the sialic acid modifying enzyme CMAH in human THP1 macrophages
(2018-09-03)
Throughout evolutionary processes, organisms gain or lose functions because of emerging mutations. The frameshift mutation emerged in the human CMAH gene is one of these loss of function mutations and it caused the human ...
Functional in vivo calcium imaging in the hippocampus under healthy and disease conditions
(2020-04-22)
The hippocampus has long been known to be essential for all features of memory processing. Hippocampal function strongly depends on the orchestrated activity of transiently autonomous neuronal populations that create the ......
TREM2 modulates differential deposition of post-translationally modified Aβ variants in the brain parenchyma and the vasculature
(2022-08-01)
Alzheimer’s disease (AD) is characterized by the combined presence of extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles (NFTs) with abnormally phosphorylated tau (t) protein in the ...
AI Models for Modeling and Simulation of Clinical Studies for Alzheimer's and Parkinson's Disease
(2023-08-14)
Neurodegenerative diseases (NDDs) have a complex structure and most of them are untreatable that’s why more research studies undertake translational paths for getting better insights into prevention, early detection, and ...
Molecular Mechanisms of Aβ Peptide Aggregation and Interaction with Microglia via TREM2
(2024-01-22)
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder accompanied by a decline in cognitive functions. It is estimated that roughly 50 million people are currently suffering from AD, a number that is thought ...