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Extracellular vesicles derived from Hepatitis-D Virus infected cells induce a proinflammatory cytokine response in human peripheral blood mononuclear cells and macrophages
(2020-02-14)
Hepatitis D Virus (HDV) is a satellite virus requiring a Hepatitis B Virus (HBV) envelope
proteins for productive infection. Hepatitis D is the most severe form of viral hepatitis
and is a global health threat affecting ...
Intervertebral Disc and Adipokine Leptin—Loves Me, Loves Me Not
(2020-12-31)
Leptin—the most famous adipose tissue-secreted hormone—in the human body is mostly observed in a negative connotation, as the hormone level increases with the accumulation of body fat. Nowadays, fatness is becoming another ...
Assessing the quality of life of patients with metastatic castration-resistant prostate cancer with bone metastases receiving [223Ra]RaCl2 therapy
(2020-08-19)
[223Ra]RaCl2 dichloride treatment in patients with metastatic castration-resistant prostate cancer (mCRPC) is associated with improved overall survival (OS) and a delay in the time to the first ...
UDP-glucuronosyltransferase polymorphisms affect diethylnitrosamine-induced carcinogenesis in humanized transgenic mice
(2020-08-28)
UDP-glucuronosyltransferase (UGT) 1A enzymes detoxify a broad array of exogenous compounds including environmental toxins and carcinogens. Case-control studies identified genetic variations in UGT1A genes leading to reduced ...
The DEAH helicase DHX36 and its role in G-quadruplex-dependent processes
(2020-10-12)
DHX36 is a member of the DExD/H box helicasefamily, which comprises a large number of proteinsinvolved in various cellular functions. Recently, thefunction of DHX36 in the regulation of G-quadruplexes(G4s) was demonstrated. ......