Fakultäten der Universität Bonn: Suche
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Synthesis, optimization, and characterization of chromen-4-one and 1,7-phenanthroline derivatives as ligands for the orphan G protein-coupled receptors 35 and 84
(2021-06-21)
G protein-coupled receptors (GPCRs) are ideal drug targets. Their characteristic tissue distribution, marked ligand specificity, and their roles in countless (patho)physiological processes are being exploited by more than ...
Between Town and Monastery: Peasant economy in the first millennium AD
(2021-11-16)
Approaches to early medieval peasantry are often polarized, either enhancing the benefits brought by the weakening of aristocratic dominance or emphasizing the limited prospects for peasant development in the absence of a ...
Translatome analysis and in vivo Ca2+ imaging of astrocytes in an Alzheimer’s disease mouse model
(2021-03-18)
One of the most prominent hallmarks of Alzheimer’s Disease (AD) is the accumulation of amyloid beta (Abeta) species, which have the tendency to form extracellular insoluble Abeta plaques and induce reactive astrogliosis ...
Regulation of inflammasome activation: roles for phospholipase C and mitochondria
(2021-08-05)
Inflammasomes are protein complexes serving as activation platforms for the protease caspase-1, which leads to a pro-inflammatory type of cell death termed pyroptosis and to maturation and release of the cytokines interleukin- ......
Medicinal chemistry and molecular pharmacology of orphan human Mas-related G protein-coupled receptors X2 and X4 (MRGPRX2 and MRGPRX4)
(2021-10-19)
The MRGPRX protein subfamily comprise rhodopsin-like orphan GPCRs, whose endogenous agonists have not been identified yet. They are exclusively expressed in primates, including humans. All Mas-related GPCRs (MRGPRs) were ...
Characterization of the pro-inflammatory activity of short-chain fatty acids (SCFAs)
(2021-10-13)
Short-chain fatty acids (SCFAs), which are mainly derived from microbial fermentation of dietary fibres, have been considered to be beneficial to gut health for decades. Recently, a few of studies reported that some patients ...
Biomarkers and Correlates of Aging
(2021-10-19)
The rapid aging of the global population, often accompanied by disabilities and various age-related diseases, is becoming a major public health burden (WHO 2015). Stimulating healthy aging is therefore of tremendous ...
Efficient calibration strategies for panoramic terrestrial laser scanners
(2021-01-25)
Terrestrial laser scanner (TLS) measurements are unavoidably affected by systematic errors due to internal mechanical misalignments, while the calibration is the fundamental procedure for mitigating these effects and ...
Wissenschaftliches Arbeiten: Leitfaden zur Erarbeitung von Studien- und Prüfungsleistungen am Kunsthistorischen Institut der Universität Bonn
(2021)
Mit diesem Leitfaden möchten wir Ihnen eine Unterstützung beim Erbringen Ihrer Studien- und Prüfungsleistungen für das Fach Kunstgeschichte anbieten. Insbesondere wenn Sie am Anfang Ihres Studiums stehen, sollen Ihnen die ...
Structural and Functional Changes in the Cerebellum in Sporadic Ataxias
(2021-01-26)
Sporadic ataxia is a group of progressive neurodegenerative diseases that can be subdivided into two groups, sporadic adult onset ataxia (SAOA), and the cerebellar type of multiple system atrophy (MSA-C). In the first years ...