Fakultäten der Universität Bonn: Suche
Anzeige der Dokumente 701-710 von 732
Implementation of a high throughput screening assay to identify and characterize insecticides acting on ion channels
(2023-11-03)
With 800 million people suffering from hunger, new innovative crop protection products are required to ensure food supply and stop hunger.
The voltage-sensitive sodium channel (VSSC) was shown to be a safe and effective ...
Platelets shape the immune response of primary human monocytes
(2023-01-13)
Monocytes are circulating immune cells essential to host defense, orchestrating immune responses through the secretion of immunomodulatory mediators. While exuberant monocyte-driven immune responses have life-threatening ...
Innovative Pharmaceutical Stabilization and Formulation Techniques for Protein Drugs
(2023-12-18)
Solid protein formulations for peroral, nasal or parenteral administration would significantly improve the therapeutic use, compliance, and stability of protein-based drugs. The aim of this work was to develop, apply, and ...
Evaluation of permeation of active pharmaceutical ingredients through outer biological barriers for topical application
(2024-01-29)
(noch nicht zugänglich / not yet accessible)
Deep Generative Modelling in Systems Medicine: From Transcriptomics Data to Drug Development
(2024-02-02)
(noch nicht zugänglich / not yet accessible)
Elucidating the Role of Long Noncoding RNA H19 in Aortic Valve Disease
(2024-02-02)
(noch nicht zugänglich / not yet accessible)
The chromatin organizer Satb1 regulates the differentiation into CD4+ TH subsets and is essential for the development of TH17 cells
(2021-06-04)
CD4+ T cells play a critical role in host defense and tissue homeostasis. Upon encountering their specific antigen, naive CD4+ T cells can differentiate into the effector T helper (TH) subsets ...
In vivo Relevant Drug Product Evaluation by Using the Biphasic Dissolution Assay (BiPHa+)
(2022-06-13)
An increasing number of new chemical entities struggled with a very poor solubility in aqueous media. Solubility or the ability to dissolve in intestinal media is obligatory for oral bioavailability. Dealing with this ......
Modulation der Expression und Funktion kardialer Gap Junction Kanäle
(2024-02-09)
Die elektrische Kopplung von Kardiomyozyten (KMs) im Herzen wird durch Connexine (Cx) vermittelt. Diese stellen durch die Bildung von Gap Junctions (GJs) Zell-Zell-Kontakte zwischen benachbarten KMs her. Im Herzmuskel ist ......
X-Ray Crystallography of G Protein-coupled Receptors: Exploring Interactions with Drug Molecules
(2023-01-19)
(noch nicht zugänglich / not yet accessible)