Medizinische Fakultät: Suche
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Pharmacologic intervention in macrophage metabolism: Mitochondrial pyruvate carrier inhibition by Mitoglitazone modulates inflammation
(2023-08-09)
Upon Toll-like receptor (TLR) activation, macrophages rapidly change their transcriptional- and translational network and rewire their metabolism. Mitochondrial pyruvate import via the mitochondrial pyruvate carrier (MPC) ...
Legionnaires' Disease - the impact of cigarette smoke and functional lung recovery
(2023-02-14)
Legionnaires’ Disease is a severe type of pneumonia most commonly caused by the bacterial species Legionella pneumophila and Legionella longbeachae. Epidemiological studies show that cigarette smoke is a major risk factor ......
Primary cilia and their effects on immune cell functions and metabolism: a model
(2022-05)
Primary cilia are hair-like protrusions of the plasma membrane that function as cellular antennae and are present on most cells in the human body. Primary cilia dysfunction leads to severe diseases, commonly termed ...
Characterization of the zinc-sensitive metal-regulatory transcription factor 1 in hippocampal epileptic network formation using an animal model of Temporal Lobe Epilepsy
(2023-10-02)
Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy. It usually occurs after a transient brain insult, including status epilepticus (SE), which triggers a latent period of epileptogenesis prior to the ......
A basal forebrain to midbrain circuit drives exploratory locomotion
(2023-10-26)
Locomotion is a fundamental behavior that comprises different specialized neuronal networks. In the basal forebrain, the glutamatergic neurons of the medial septum and diagonal band of Broca (MSDBglu) can initiate ......
Role of the chemokines CCL17 and CCL22 in bacterial infection and IL-33-induced immune responses
(2023-11-24)
The chemokines CCL17 and CCL22 are primarily expressed by dendritic cells (DC) and macrophages. Both chemokines share the receptor CCR4, which is expressed on DC and macrophages as well as on a variety of different T cell ......
Investigating the ability of RIG-I agonists to provide protection in mouse and ferret models of respiratory virus infection
(2022-05-17)
Respiratory infections caused by influenza A virus (IAV) or respiratory syncytial virus (RSV) lead to substantial morbidity and mortality. Treatment options are limited and there is urgent need for the development of ......
Characterization of the pro-inflammatory activity of short-chain fatty acids (SCFAs)
(2021-10-13)
Short-chain fatty acids (SCFAs), which are mainly derived from microbial fermentation of dietary fibres, have been considered to be beneficial to gut health for decades. Recently, a few of studies reported that some patients ...
Functional and cellular heterogeneity of the myeloid cell system
(2020-11-09)
Cells of the myeloid lineage form the innate part of the immune system and are characterized by a high level of functional plasticity, which is required to address the diverse set of functions of these mononuclear cells. ...
RIM4 deficiency leads to reduced somato-dendritic excitability of cerebellar Purkinje cells
(2023-12-14)
Synaptic function is determined by the release machinery at the active zone which is composed of a large number of synaptic proteins including RIMs. The large RIMs are key components of the presynaptic active zone that ...