Medizinische Fakultät
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E-Dissertationen (1901)
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Publikationen (7)
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Verbesserung der KI-gestützten Detektion von fokalen kortikalen Dysplasien mittels gemeinsamer Datennutzung
(2025-06-05)Fokale kortikale Dysplasien (FCDs) gehören zu den strukturellen Veränderungen des Gehirns, die häufig eine therapieresistente fokale Epilepsie verursachen. Bei FCDs handelt es sich um eine Fehlbildung der kortikalen ... -
Differential modulation of resting-state functional connectivity between amygdala and precuneus after acute physical exertion of varying intensity: Indications for a role in affective regulation
(2024-04-04)<strong>Introduction:</strong> Physical activity influences psychological well-being. This study aimed to determine the impact of exercise intensity on psychological well-being and alterations in emotion-related brain ... -
Is There Variation in the Morphology of the Frontal Sinus in Individuals with Different Craniofacial Patterns?: A Systematic Review with Meta-Analysis
(2024-05-15)To evaluate differences in the morphology of the frontal sinus in adolescents and adults with different craniofacial patterns, searches up to April 2024 were conducted in six databases and other information sources to ... -
Evaluation des Vasoactive-Ventilation-Renal Score (VVR-Score) als Outcome-Prädiktor bei Neugeborenen mit einer angeborenen Zwerchfellhernie
(2025-05-27)Mithilfe von Schweregrad-Scores soll das Outcome von Neugeborenen mit einer kongenitalen Zwerchfellhernie (CDH) abgeschätzt werden. Der Oxygenierungsindex (OI) und der Vasoactive-Inotropic Score (VIS) wurden bereits in ... -
Die Rolle mononukleärer Phagozyten der Nebenniere in der Inflammation
(2025-05-23)In der vorliegenden Arbeit wurde untersucht, ob eine stressbedingte Produktfreisetzung der Nebenniere durch mononukleäre Phagozyten anhand von CX3CR1 beeinflussbar sein könnte. LPS-Provokation führt in Mäusen zu einer ... -
Functional analysis of the neurodevelopmental disorder candidate gene RUFY4 in Drosophila melanogaster
(2025-05-21)Neurodevelopmental disorders (NDDs) encompass a heterogeneous group of complex conditions, most of which are characterized by intellectual disability (ID). ID arises from both environmental and genetic causes, with most ... -
Aktivierung von pathogenem MCT8 mithilfe von Natriumphenylbutyrat in juvenilen Mäusen
(2025-05-20)<strong>Kontext</strong>: Mutationen im Gen <em>SLC16A2</em> verursachen die seltene, X-chromosomal vererbte MCT8-Defizienz. Die Erkrankung führt zu einer charakteristischen Kombination von Symptomen einer zentralen ... -
Klinische Symptomatik, Neuropsychologie und genetische Faktoren bei Alzheimer-Krankheit mit frühem Beginn und spätem Beginn im Vergleich
(2025-05-19)Die Alzheimer-Krankheit ist die häufigste Ursache einer Demenz. Die Inzidenz steigt mit zunehmendem Lebensalter, jedoch gibt es eine nicht zu vernachlässigende Patientengruppe, die bereits vor dem 65. Lebensjahr erkrankt. ... -
Arterial Blood Supply of the Stifle Joint in Horses
(2024-04-24)The vascularization pattern of the equine stifle joint is insufficiently described in the literature, even though there is a growing need for knowledge of the exact blood supply, as (i) arthroscopy and endoscopic surgery ... -
NECTIN4 Amplification Is Frequent in Solid Tumors and Predicts Enfortumab Vedotin Response in Metastatic Urothelial Cancer
(2024-04-24)<strong>PURPOSE</strong> The anti-NECTIN4 antibody-drug conjugate enfortumab vedotin (EV) is approved for patients with metastatic urothelial cancer (mUC). However, durable benefit is only achieved in a small, yet ... -
Optimizing Interhospital Transfers in Orthopedics and Trauma Surgery: Challenges, Insights, and Proposals for Standardized Care in Germany
(2024-05-08)Background: Germany’s high density of under-equipped hospitals and anticipated surge in orthopedic and trauma surgery-related diseases by 2030, combined with personnel shortages, are expected to increase patient transfers ... -
‘We are all in the same boat’: a qualitative cross-sectional analysis of COVID-19 pandemic imagery in scientific literature and its use for people working in the German healthcare sector
(2024-02-05)<strong>Background:</strong> The COVID-19 pandemic presents a significant challenge to professional responders in healthcare settings. This is reflected in the language used to describe the pandemic in the professional ... -
Infective Endocarditis Requiring Mitral Valve Replacement During Second Trimester of Pregnancy
(2024-06-05)Infective endocarditis requiring mitral valve replacement during pregnancy is a rare event. We present a case of infective endocarditis of the mitral valve during second trimester and report maternal and perinatal outcomes. ... -
Fractional amplitude of low-frequency fluctuations associated with μ-opioid and dopamine receptor distributions in the central nervous system after high-intensity exercise bouts
(2024-02-22)<strong>Introduction:</strong> Dopaminergic, opiod and endocannabinoid neurotransmission are thought to play an important role in the neurobiology of acute exercise and, in particular, in mediating positive affective ... -
Mass Spectrometry-Based Profiling of Histone Post-Translational Modifications in Uveal Melanoma Tissues, Human Melanocytes, and Uveal Melanoma Cell Lines: A Pilot Study
(2024-02-13)<strong>PURPOSE.</strong> Epigenetic alterations in uveal melanoma (UM) are still neither well characterized, nor understood. In this pilot study, we sought to provide a deeper insight into the possible role of epigenetic ... -
Is a mass drug administration deworming programme for school-aged children enough to reduce the prevalence of soil-transmitted helminths and Schistosoma mansoni in adults: a cross-sectional study from Togo
(2024-02-13)<strong>Background:</strong> The world health organization (WHO) introduced the mass drug administration (MDA) strategy in order to reduce the prevalence of soil-transmitted helminths (STHs) and <em>Schistosoma mansoni</em> ... -
Modulation of cytomegalovirus immune evasion identifies direct antigen presentation as the predominant mode of CD8 T-cell priming during immune reconstitution after hematopoietic cell transplantation
(2024-02-15)Cytomegalovirus (CMV) infection is the most critical infectious complication in recipients of hematopoietic cell transplantation (HCT) in the period between a therapeutic hematoablative treatment and the hematopoietic ... -
Rapid protection against viral infections by chemokine-accelerated post-exposure vaccination
(2024-01-29)<strong>Introduction:</strong> Prophylactic vaccines generate strong and durable immunity to avoid future infections, whereas post-exposure vaccinations are intended to establish rapid protection against already ongoing ... -
Beeinflussung der zirkadianen Rhythmik von Parodontalligamentzellen durch mechanischen Stress
(2025-04-28)Im menschlichen Organismus nimmt die zirkadiane Rhythmik eine zentrale Rolle ein. Eine periphere zirkadiane Rhythmik konnte schon in einigen Zelltypen wie den parodontalen Ligamentzellen (PDL-Zellen), nachgewiesen werden. ... -
The role of microRNAs in defining LSECs cellular identity and in regulating F8 gene expression
(2024-02-19)<strong>Introduction:</strong> Coagulation Factor VIII (FVIII) plays a pivotal role in the coagulation cascade, and deficiencies in its levels, as seen in Hemophilia A, can lead to significant health implications. Liver ...
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