The Faculty of Medicine
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E-Dissertationen (1895)
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Publikationen (7)
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Beeinflussung der zirkadianen Rhythmik von Parodontalligamentzellen durch mechanischen Stress
(2025-04-28)Im menschlichen Organismus nimmt die zirkadiane Rhythmik eine zentrale Rolle ein. Eine periphere zirkadiane Rhythmik konnte schon in einigen Zelltypen wie den parodontalen Ligamentzellen (PDL-Zellen), nachgewiesen werden. ... -
The role of microRNAs in defining LSECs cellular identity and in regulating F8 gene expression
(2024-02-19)<strong>Introduction:</strong> Coagulation Factor VIII (FVIII) plays a pivotal role in the coagulation cascade, and deficiencies in its levels, as seen in Hemophilia A, can lead to significant health implications. Liver ... -
Wirkung und Wirkdauer akuter körperlicher Aktivität auf das Entscheidungsverhalten von Erwachsenen mit Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung
(2025-04-25)Die Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) betrifft etwa 4,7 % der Erwachsenen in Deutschland und ist mit Einschränkungen in Bildung, sozialen Kompetenzen und Lebensqualität verbunden. Ein zentrales Merkmal ... -
Associations between COVID-19 Pandemic-Related Overtime, Perceived Chronic Stress and Burnout Symptoms in German General Practitioners and Practice Personnel: A Prospective Study
(2024-02-16)Background: The mental burdens of general practitioners (GPs) and practice assistants (PrAs) during the COVID-19 pandemic are well investigated. Work-related conditions like overtime are known to contribute to perceived ... -
Physiochemical and mechanical characterisation of orthodontic 3D printed aligner material made of shape memory polymers (4D aligner material)
(2023-12-25)<em>Objectives:</em> To conduct a physiochemical and mechanical material analysis on 3D printed shape-memory aligners in comparison to thermoformed aligners.<br /> <em>Materials and methods:</em> Four materials were examined, ... -
Spirituality and anxiety in pastoral care workers and physicians in the first wave of the COVID-19 pandemic
(2024-03-11)<strong>Background:</strong> The COVID-19 pandemic had serious impact on the well-being of health care workers and highlighted the need for resources to help hospital staff to cope with psychologically negative consequences. ... -
Identification of presynaptic proteins as neddylation targets
(2025-04-22)Reversible post-translational modifications are essential for the regulation of cell functions. One such modification is the attachment of ubiquitin and ubiquitin-like proteins, including Nedd8 (neural-precursor-cell-expressed ... -
Scalable Methods and Algorithms for Detecting Specific DNA Changes in Clinical Patients and Offspring of Radar-Exposed Personnel: A transgenerational biomarker of paternal exposure to ionizing radiation
(2025-04-17)The abundance of Whole genome sequencing (WGS) data now enables research into more complex phenotypes and into effects of Ionizing radiation (IR) on human DNA. We used WGS data to contribute to four advances: 1. Finding a ... -
Dissecting mechanisms of CD8+ T cell-mediated control of metastatic melanoma
(2025-04-14)Although CD8+ T cells can play an anti-tumoural role in cancer, they often fail to do so, in part due to the acquisition of an ‘exhausted’ or ‘dysfunctional’ state. Different T cell subsets have been identified in this ... -
Voxel-basierte Morphometrie bei Ataxie-Krankheiten des höheren Erwachsenenalters
(2025-04-14)In der vorliegenden Arbeit wurden die Volumenveränderungen des Gehirns RFC1-positiver CANVAS-Patienten mittels voxel-basierter Morphometrie untersucht. Diese wurden anschließend mit gesunden Kontrollpersonen sowie SCA6- ... -
Investigation of Interplay between Neuropilin-2, EGFR and Radiation in Prostate Cancer and Head and Neck Squamous Cell Carcinoma
(2025-04-14)Aim the thesis is to explore how NRP2, EGFR, and radiation interact in relation to PCa and HNSCC. NRP2 and EGFR are known to play crucial roles in tumor development, progression, and treatment resistance. Nevertheless, the ... -
TNIP1 affects proliferation, apoptosis and migration of Human Embryonic Kidney 293 cells
(2025-04-14)TNIP1 is a protein associated with autophagy and inflammation, which is ubiquitously expressed in the brain. It mediates extracellular signals such as growth factor signaling, influences nuclear expression patterns driven ... -
Charakterisierung hereditärer und situativer Risikofaktoren für venöse Thrombosen ungewöhnlicher Lokalisation
(2025-04-14)Hintergrund: Venöse Thromboembolien (VTE) treten am häufigsten in den tiefen Venen der unteren Extremitäten auf. Thrombosen an atypischen Lokalisationen wie der oberen Extremität (TVT-OE), im splanchnischen (SVT) oder ... -
Vermessung der geometrischen und densitometrischen Eigenschaften des vorderen Augenabschnitts von Kindern und Jugendlichen im Alter von drei bis zwanzig Jahren
(2025-04-04)Der vorliegenden Dissertationsschrift liegt eine Studie zugrunde, welche die Vermessung des vorderen Augenabschnitts bei Kindern und Jugendlichen in Bezug auf geometrische und densitometrische Daten zum Gegenstand hat. ... -
Generation of an isogenic stem cell model to decipher the pathogenesis of SYNGAP1 syndrome in human neurons
(2025-04-03)The synaptic GTPase-activating protein SynGAP is an important constituent of the postsynaptic compartment. Haploinsufficiency of the SYNGAP1 gene is associated with a neurodevelopmental disorder characterized by mental ... -
Auswirkungen der COVID-19 Pandemie auf die Qualitätsversorgung eines interdisziplinären Notfallzentrums an einem deutschen Universitätsklinikum: eine retrospektive observatorische Erhebung
(2025-04-02)Infektionskrankheiten wie COVID-19 führen zu erheblichen Herausforderungen in der Notfallversorgung und beeinflussen das Patientenverhalten nachhaltig. Diese Dissertation untersucht die Auswirkungen der COVID-19-Pandemie ... -
Antagonistic Nanobodies Reveal Mechanism of Gasdermin D Pore Formation and Unexpected Therapeutic Potential
(2025-04-01)Activation of various inflammasomes converges on the cleavage of gasdermin D (GSDMD) by pro-inflammatory caspases, followed by oligomerization of the N-terminal domain (GSDMD<sup>NT</sup>) and the assembly of pores penetrating ... -
Contribution of common genetic variants to disease status and symptom dimensions in affective and psychotic disorders
(2025-04-01)Affective and psychotic disorders, such as major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia spectrum disorders (SSD), represent complex psychiatric conditions with a moderate to high heritability. ... -
Longitudinal analysis of morphological and functional changes in intermediate age-related macular degeneration
(2025-04-01)Purpose: Longitudinal analysis of retinal thickness changes of mesopic as well as scotopic retinal function in patients with iAMD.<br /> Methods: Fifty-nine eyes of 54 AMD patients with large drusen (>125 µm) underwent ... -
Anwendung einer neuen Light-Induced Fluorescence basierten Methode zur quantitativen Erfassung von Plaque bei Probanden mit Multi-Bracket-Apparaturen
(2025-04-01)Allgemeines – Dentale Plaque ist ein wesentlicher Faktor bei der Entstehung von Karies. Vor allem bei Patienten unter Multiband-/ Multibrackettherapie kann sich leicht Plaque anlagern. Meist lagert sich die Plaque im Bereich ...
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