The Faculty of Medicine: Search
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T cell response to an MHC-II restricted epitope of rodent malaria
(2022-02-01)
Malaria is caused by different Plasmodium species that can infect a variety of animals including humans and rodents. The life cycle of these parasites is complex and includes a liver stage followed by a blood-stage in their ......
Understanding telomere dynamics with G-quadruplex secondary structures in S. cerevisiae
(2022-03-10)
Telomeres are specialized nucleoprotein structures at the end of linear eukaryotic chromosomes, vital for safeguarding of genetic material. They inhibit nucleolytic degradation, end to end fusion and unwanted recombination. ......
The role of sympathetic neurons in modulating resident muscularis macrophage functions during postoperative ileus and mucosal antimicrobial responses in homeostasis: Sympathetic neurons in intestinal homeostasis and disease
(2022-02-09)
Introduction: The sympathetic nervous system (SNS) innervates large parts of the gastrointestinal tract. Its projections are densely found in tunica muscularis externa and reach up to the mucosa, the ...
Search for exosomes in NG2-glial cells
(2022-02-17)
NG2-glial cells is an abundant and widely distributed subtype of glia, featuring properties not typically associated with mature glial cells, such as the ability to receive synaptic input from neurons, or adult proliferation. ...
Investigation of novel pathways causing autoinflammatory disease
(2022-05-17)
Autoinflammatory diseases (AIDs) are rare pathologies caused by mutations in genes associated with innate immune pathways. Investigating the underlying molecular defects contributes to identification of targeted treatment ......
Global 3’-UTR Length Changes Form a Novel Layer of Regulation in the Macrophage Response to Interferon-Beta
(2022-05-20)
Interferon signaling is one of the most important mechanisms shaping innate immune responses and needs to be tightly regulated to successfully fight infections and modulate immune responses while avoiding toxicity.
The role of innate lymphoid cells in liver disease: Identification of a hepatic IL-13-producing ILC3-like population potentially involved in liver fibrosis
(2022-05-23)
Innate lymphoid cells (ILCs) are a family of innate immune cells that mirror the functionality of T lymphocytes but do not express rearranged antigen receptors. As tissue-resident cells, ILCs primarily reside in peripheral ...
Role of IFN‑γ induced genes in cell autonomous defence against Legionellae
(2022-05-27)
L. pneumophila and L. longbeachae are ubiquitous environmental bacteria that can cause a severe pneumonia, known as Legionnaires’ Disease, when contaminated aerosols are inhaled by susceptible humans. During ......
Interplay of IKKs and IKK-related kinases in antiviral nucleic acid receptor signaling in human monocytes
(2022-06-21)
Monocytes and monocyte-derived cells are among the first line of host defense against
invading pathogens. They are equipped with pattern recognition receptors (PRRs) that
detect conserved components of microbes and in ...
Participation of Ste20-like kinase-deficient neurons in the abnormal circuitry of focal epileptogenic lesions
(2022-01-03)
Focal epileptogenic lesions displaying morphologically altered neurons are frequently associated with devastating and therapy-refractory epilepsies. However, it is still unsolved how dysplastic neurons contribute to the ...