The Faculty of Medicine: Medizinische Fakultät: Recent submissions
Now showing items 361-380 of 2398
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Assessment of local sensitivity in incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) lesions in intermediate age-related macular degeneration (iAMD)
(2024-07-09)<strong>Objective</strong> Lesions of incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) are associated with disease progression in intermediate age-related macular degeneration (AMD). However, the ... -
Placental Sonomorphologic Appearance and Fetomaternal Outcome in Fontan Circulation
(2024-09-01)<strong>Objectives:</strong> Pregnancies in women with Fontan circulation are on the rise, and they are known to imply high maternal and fetal complication rates. The altered hemodynamic profile of univentricular circulation ... -
The role of RER1 in the assembly and transport of TREM2-DAP12 complex and cellular lipid metabolism
(2025-07-25)DNAX-activating protein of 12 kDa (DAP12) is a transmembrane adapter protein expressed on lymphoid and myeloid lineage cells, and interacts with several immune receptors to form functional complexes that trigger intracellular ... -
Modelling structure-function relationships from neurons to networks in the cerebral cortex
(2025-07-24)Using a multi-scale model based on extensive experimental data, I explored structure-function relationships in cortex. At a macro-scale, I used ANNs with cortical features to show that sparse connectivity enables efficient ... -
Targeting tumor cells with cytokine-induced killer cells and bifunctional peptides
(2025-07-23)Antimicrobial peptides have gained much attention in clinical research due to their extensive possibilities of application beyond antimicrobial use. The modification of antimicrobial peptides enables the peptides to target ... -
Das Hitzeschockprotein GRP78 als Biomarker für Diagnose und Prognose bei Patienten mit Koronarer Herzerkrankung
(2025-07-23)Das Hitzeschockprotein Glucose-regulated-protein-78 (GRP78) hat einen entscheidenden Einfluss auf die Homöostase im endoplasmatischen Retikulum und ist maßgeblich an der Antwort auf Stress des endoplasmatischen Retikulums ... -
Synthetic diets exacerbate auto-immunity in mice: EAE stage resolved proteomic immune cell characterization
(2025-07-23)Western diet (WD)-associated non-communicable diseases (NCDs), including metabolic syndrome, and neurodegenerative conditions like multiple sclerosis (MS), are leading causes of death in the Western world. Although our ... -
Non-invasive physical plasma as an oncological therapy option: Modulation of cancer cell growth, motility, and metabolism without induction of cancer resistance factors
(2025-07-23)<strong>Background:</strong> Physical plasma, the fourth state of matter formed through gas ionization, has shown promise in various clinical applications, including wound healing and antimicrobial therapy. Recently, ... -
The impact of the mesoprefrontal dopaminergic system on the maturation of interneurons in the murine prefrontal cortex
(2024-07-05)The prefrontal cortex (PFC) undergoes a protracted maturation process. This is true both for local interneurons and for innervation from midbrain dopaminergic (mDA) neurons. In the striatum, dopaminergic (DA) neurotransmission ... -
Demirjian's and Cameriere's Methods for the Assessment of Dental Age Estimation in Children from a Southern Brazilian City
(2024-07-13)The chronological age estimation of living individuals is a crucial part of forensic practice and clinical practice, such as in orthodontic treatment. It is well-known that methods for age estimation in living children ... -
Long-term seizure outcome after epilepsy surgery of neuroglial tumors
(2024-05-23)<strong>Purpose:</strong> Neuroglial tumors are frequently associated with pharmacorefractory epilepsies. However, comprehensive knowledge about long-term outcomes after epilepsy surgery and the main prognostic factors for ... -
Regenerative Parodontalchirurgie und kieferorthopädische Zahnbewegung bei Stadium IV Parodontitis: Ergebnisse klinischer Studien
(2025-07-21)Parodontitis im Stadium IV ist charakterisiert durch schweren Verlust an parodontalem Attachment, vertikale Knochendefekte und pathologische Zahnwanderung (PTM). Die Komplexität des Krankheitsbildes aufgrund von PTM - ... -
Molekulargenetische Verfahren zur Untersuchung der Patienten- und Umgebungsmikrobiom-assoziierten Krankheitsentstehung und -dynamik
(2025-07-18)Die präsentierten Ergebnisse unterstreichen die Bedeutung des Mikrobioms nicht nur als Indikator für gesundheitliche Zustände, sondern auch als aktiven Teilnehmer in der Krankheitsentwicklung. Durch die detaillierte Analyse ... -
Attention Deficit Hyperactivity Disorder: A Risk Factor for Premature Discontinuation of Inpatient Opioid Withdrawal Treatment
(2024-06-03)<strong>Background:</strong> Substance use disorders present a tremendous challenge within contemporary healthcare systems. Specifically, in the domain of opioid use disorders (OUDs), several foundational elements are ... -
Severe autoimmune hemolytic anemia following immunotherapy with checkpoint inhibitors in two patients with metastatic melanoma: a case report
(2024-03-20)<strong>Introduction:</strong> Over the past decade, immune checkpoint inhibitors such as antibodies against cytotoxicity T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) have become ... -
Comparative development of human filariae Loa loa, Onchocerca volvulus and Mansonella perstans in immunocompromised mouse strains
(2024-04-15)<strong>Introduction:</strong> Mouse models of human filarial infections are not only urgently needed to investigate the biology of the nematodes and their modulation of the host's immunity, but will also provide a platform ... -
The unusual mode of action of the polyketide glycoside antibiotic cervimycin C
(2024-05-09)Cervimycins A–D are bis-glycosylated polyketide antibiotics produced by <em>Streptomyces tendae</em> HKI 0179 with bactericidal activity against Gram-positive bacteria. In this study, cervimycin C (CmC) treatment caused a ... -
The role of dendritic cells in MASH: friends or foes?
(2024-04-08)Dendritic cells (DCs) are major antigen-presenting cells that connect innate and adaptive immunity. Hepatic DCs are less activated and contribute to maintain the tolerogenic environment of the liver under steady state. ... -
Generation of a Generic Nanobody-based CAR-T Cell Platform
(2025-07-16)Recent advances in cancer therapy, particularly immune checkpoint blockade (ICB), have significantly improved immune responses against tumors. However, many patients do not respond to ICB, and some experience disease ... -
Entwicklung der Morbidität und Komorbidität in einem kardiologischen Reha-Setting von 2006 bis 2019: Eine unizentrische Studie
(2025-07-15)Einleitung / Problemstellung<br /> Die klinische Beobachtung zeigte, dass Veränderungen in der Akutmedizin langfristig auch zu Auswirkungen in der kardiologischen Rehabilitation führten. Systematische Untersuchungen zu ...
