The Faculty of Mathematics and Natural Sciences: Browsing Mathematisch-Naturwissenschaftliche Fakultät by Title
Now showing items 1518-1537 of 4366
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Functional characterization of Gαi/s proteins and modulation of their activity by linear and cyclic peptides
Pepanian, Anna (2024-01-30)Heterotrimeric Gαβγ (guanine nucleotide-binding) proteins serve as molecular switches to activate (“switch on”) or inactivate (“switch off”) diverse intracellular signaling cascades in response to stimulated G protein-coupled ... -
Functional Characterization of Interaction Partners of the Co-Chaperone BAG3
Zeidler, Claudia (2018-04-23)Protein homeostasis (proteostasis) describes the cellular balance between protein synthesis, function and degradation. The stress inducible co-chaperone BAG3 is a key factor in proteostasis, in particular under mechanical ... -
Functional characterization of neuron-NG2 cell synaptic transmission
Paßlick, Stefan (2014-09-11)NG2 cells are nowadays considered as a fourth class of glial cells in the CNS. They express various types of voltage-gated ion channels and neurotransmitter receptors and exhibit the capability to proliferate and differentiate. ... -
Functional characterization of the 5-oxo-ETE receptor OXE-R and identification of the first small molecule antagonist with a novel mechanism of ligand bias
Blättermann, Stefanie (2011-10-21)The lipid mediator 5-oxo-ETE (OXE) is a metabolite of the 5-lipoxygenase pathway and acts as a potent chemoattractant on eosinophils and neutrophils. OXE-induced effects are mediated via the G<sub>i</sub> coupled 5-oxo-ETE ... -
Functional characterization of the synaptic-activity regulated gene Synaptotagmin10
Woitecki, Anne Maria Helena (2013-12-10)During epileptogenesis multiple cellular and molecular changes occur in the brain resulting in the emergence of recurrent spontaneous seizures. One member of the Synaptotagmin (Syt) gene family that is rapidly and transiently ... -
Functional Characterization of Transgenic Arabidopsis thaliana Plants Co-over expressing Aldehyde dehydrogenases and Genes for Soluble Osmolytes
Raza, Hasnain (2010-09-16)Plant growth and productivity is largely hampered by a number of abiotic stresses. These stresses affect the physiological and metabolic pathways leading to the production of many harmful substances like aldehydes, reactive ... -
Functional Characterizations of the Reciprocal Interaction of the Circadian Clock gene Time for coffee (TIC) with Stress and Energy in Arabidopsis
Du, Shenxiu (2017-03-08)Circadian clocks are important time-environment response mechanism that provide adjustment and adaptation for light, dark, warm, cold or wet, dry altering; some of the altering even caused stresses in plants. The Arabidopsis ... -
Functional consequences of ε AChR subunit truncating mutations linked to Congenital Myasthenic Syndrome
Gurgui, Cristian (2005)Congenital myasthenic syndromes (CMS) are inherited disorders due to presynaptic, synaptic, or postsynaptic defects of neuromuscular transmission. Some previously described kinships with typical signs of postsynaptic CMS ... -
Functional cooperation of Toll-like receptor signaling and the high-affinity receptor for IgE, FcεRI, on human Langerhans cells
Leib, Nicole (2018-01-15)Atopic dermatitis (AD) is a multifactorial severe skin disease with increasing incidence in western countries. In the disease, Langerhans cells (LC) play a pivotal role in bridging innate and adaptive immunity through ... -
Functional impact of Kir4.1 channels in hippocampal NG2 glia on neuronal plasticity and behavior
Timmermann, Aline (2020-08-25)NG2 glia represents the 4th type of CNS glial cells. In white matter, most of them differentiate into myelinating oligodendrocytes but in grey matter a majority retains their NG2 phenotype throughout life. Intriguingly, ... -
Functional impacts of transgenic overexpression of UDP-galactose: ceramide galactosyltransferase and polysialyltransferase on the development of oligodendrocytes and myelin maintenance
Ngamli Fewou, Simon (2005)1 PLP-CGT TRANSGENIC MICE<br /> Galactosylceramide (GalC) and its sulfated derivative (sulfatide) are major lipid components of the myelin membrane constituting about 30% of its lipid content. They fulfill essential functions ... -
Functional Inequalities and Heat Kernel Asymptotics on Some Classes of Singular Riemannian Manifolds
Oikonomopoulos, Dimitrios (2019-11-13)This thesis consists of two parts.<br /> In the first part we are focusing on stratified pseudomanifolds equipped with an iterated edge metric. More specifically, in Chapter 1 we give the basic definitions and review some ... -
Functional Integration of Floral Plant Traits: Shape and Symmetry, Optical Signal, Reward and Reproduction in the Angiosperm Flower
Mues, Andreas Wilhelm (2020-05-12)Pollination syndromes represent groups of floral phenotypes that have originated and diversified in interaction with biotic and abiotic pollen vectors. Plant trait pattern that constitute respective syndromes have been ... -
Functional investigation of cannabinoid receptors
Date, Rahul Anant (2008)The endocannabinoid system performs various regulatory functions and has been implicated in a growing number of physiological roles. In an animal model for cutaneous contact hypersensitivity (CHS), we show that mice lacking ... -
Functional markers for cerebral norepinephrine deficiency in Alzheimer's disease
Kiven, Verena Maria (2021-02-17)Pathological alterations of the locus coeruleus (LC)-norepinephrine (NE) system occur early in the course of Alzheimer’s disease (AD), and manifest in poor attention and distractibility. Cortical NE is released from the ... -
Functional Modulation of Activated Protein C using DNA-Aptamers
Shahidi Hamedani, Nasim (2017-03-15)Aptamers are single stranded DNA or RNA oligonucleotides which are able to interact with their designated target molecules with high affinity and specificity. The in-vitro procedure used for aptamer selection from a randomly ... -
Functional morphology of an adaptive radiation – sailfin silversides from Sulawesi as a model system
Wasiljew, Benjamin (2024-01-11)The adaptive fish radiation of sailfin silversides from Sulawesi serves as a model system for studying adaptive divergence. The phylogenetic lineage of “roundfins” is endemic to ancient Lake Matano and is composed of three ... -
Functional regions within a Q/N rich prion domain driving prion replication in the mammalian cytosol
Dürnberger, Yvonne (2017-05-15)Prions are proteinaceous infectious agents that replicate by recruiting and converting homotypic soluble proteins into growing aggregates. Prions in mammals cause transmissible spongiform encephalopthies and are composed ... -
Functional roles of the chemokine CCL17 in skin and brain immunity
Fülle, Lorenz Marc Michael (2019-02-04)The chemokines CCL17 and CCL22 represent ligands of CCR4 and are mainly produced by dendritic cells (DCs) and macrophages (Mφs) in the immune system. CCL17 was found to promote various inflammatory and allergic diseases, ... -
Functional studies on factor VIII variants containing different lengths of the B-domain AND The construction of a new helper vector for the production of helper-dependent adenovectors
Aburubaiha, Zaid A. Y. (2012-10-16)<strong>Functional studies on factor VIII variants containing different lengths of the B-domain</strong><br /> To evaluate the role of the factor VIII (FVIII) B-domain on FVIII expression, (activity and activation), we ...