The Faculty of Mathematics and Natural Sciences

3D culture conditions instruct an in vivo-like phenotype in primary microglia

Tambe, Bertrand Agbor (2025-04-01)

(noch nicht zugänglich / not yet accessible)

Dynamical Effects in Heavy-Fermion Systems

Lenk, Marvin (2025-03-27)

When atoms in solids have unfilled <em>d</em>- or <em>f</em>-orbitals, local Coulomb interaction often becomes non-negligible due to the strongly localized nature of those orbitals. A hallmark effect of such systems is the ...

Revisiting the innate immune response using systems immunology

Reusch, Nico (2025-03-26)

(noch nicht zugänglich / not yet accessible)

Spectroscopy and the Path to Laser Cooling of Zinc

Röser, David (2025-03-26)

To enable laser cooling of zinc, a deep UV laser system for the main cooling transition at 214 nm has been developed. The system relies on frequency-quadrupling a titanium-sapphire laser in two consecutive frequency-doubling ...

Population structure, reproductive behaviour and population density of the European wild boar, Sus scrofa, based on STR marker studies of hunting bags in Lower Saxony, Germany

Müller, Björn (2025-03-25)

Population densities and relative abundance of the European wild boar, Sus scrofa, has been steadily increasing throughout Europe for decades. Due to climate changes, wild boar is able to expand into climatic regions that ...

Design and Multistep Synthesis of Ligands for the GPR18 and GPR183: Related Orphan G Protein-Coupled Receptors with Immunoregulatory Functions

Perri, Filomena (2025-03-24)

(noch nicht zugänglich / not yet accessible)

Exploring and Addressing General Limitations of Compound Potency Predictions using Machine Learning

Borges Janela, Tiago (2025-03-24)

Compound potency prediction is a major task in computational drug discovery. Regression models based on machine learning (ML) approaches have become popular for small molecule potency predictions. Recently, deep learning ...

Synthesis of Chromophore Decorated Ligands and their Self-Assembly into Supramolecular Coordination Complexes

Hütgens, Sebastian (2025-03-20)

This thesis is concerned with the synthesis and characterization of chromophore decorated self-assembled coordination complexes (SCC’s). The SCC’s were constructed from ditopic bispyridine ligands as organic donor building ...

Establishment of bioanalytical workflows for the quality assessment of formulated proteins

Elsayed, Yomnah Yousry Mohammed (2025-03-17)

Proteins and peptides contribute to a significant class of therapeutic agents in the pharmaceutical market. Over the last decades, they gained growing interest due to their safety and specificity compared to small molecule ...

Rab requirements in HOPS-mediated late endosome-lysosome tethering and dissection of fusion factor requirements in Ca²⁺-dependent phagosome-lysosome fusion

Schleinitz, Ariane Christina (2025-03-17)

Through sequential fusion with early- and late endosomes (EEs and LEs) and ultimately lysosomes (LYS), a degradative (endo-)lysosome ((E)LYS is formed. Directionality of fusion is ensured by the action of Ras-like GTPases ...

Transcriptomic heterogeneity of microglia in relation to Alzheimer's disease-associated pathology and post-mortem delay

Kozlov, Stanislav Olegovich (2025-03-17)

(noch nicht zugänglich / not yet accessible)

Advanced deep learning methods for quantifying imaging biomarkers in large cohort studies

Estrada León, Edgar Santiago (2025-03-14)

Understanding the anatomical structures of the body and brain, and their influence on human health throughout the lifespan is of significant research and clinical interest. Tracking of structural changes can provide insights ...

Multi-Person Pose Tracking in Videos

Döring, Andreas (2025-03-14)

This thesis addresses the complex challenges of multi-person pose estimation and tracking in dynamic, real-world environments. Motivated by advancements in artificial intelligence and the growing need for natural human-machine ...

Investigating the molecular mechanisms involved in the developmental assembly of the mushroom body calyx in Drosophila melanogaster

Patil, Komal B. (2025-03-11)

How a circuit functions can be investigated by examining the organisation of the circuit to be able to decipher the connectivity logic and the logic of information flow within that circuit. Hence, to understand how the ...

Transverse Momentum Dependent Parton Distribution Functions from Twisted Mass Lattice QCD

Sen, Aniket (2025-03-09)

The aim of this thesis is the theoretical calculation of the unpolarized transverse momentum dependent parton distribution function (TMDPDF) from first principles using lattice QCD. TMDPDFs are important quantities that ...

Addressing Domain Shift in CNN-based Image Segmentation: From Improving Robustness to Unsupervised and Active Learning based Domain Adaptation

Sheikh, Rasha (2025-03-07)

Pixel-wise labeling of images is a common task in applications nowadays as it allows humans and machines to make sense of the content in an image and informs their decisions about subsequent steps to be taken. Examples of ...

Environmentally induced development of pulmonary monocyte-derived alveolar macrophages is controlled by Apolipoprotein E and Dectin-1

Theobald, Hannah (2025-03-06)

The lung is one of the largest barrier tissues of our body, and is constantly exposed to the environment. By inhaling, the lungs do not only take up oxygen, which is crucial for cellular respiration, but also a plethora ...