The Faculty of Mathematics and Natural Sciences: Browsing Mathematisch-Naturwissenschaftliche Fakultät by Title
Now showing items 3485-3504 of 4589
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Rockglacier Kinematics in a High Mountain Geosystem
Roer, Isabelle (2007)The study presents a regional approach for the quantification of rockglacier creep in a high mountain geosystem (Turtmann valley, Swiss Alps). <br /> By a combination of different methods, rockglacier movements were ... -
The role of ALDH in drought stress: A comparative analysis in A. thaliana and barley
Nasr Mahmoud, Abdelaziz Mohamed (2022-07-21)The work was divided into 3 major parts. The first part is studying the effect of ALDH enzymes on the redox homeostasis during oxidative stress, and the role of ALDHs during the germination, and longevity of A. thaliana ... -
The Role of Acyl-ACP Thioesterases and Glycerophosphodiester Phosphodiesterases for Gametophyte Development in Arabidopsis thaliana
Siebers, Meike (2016-08-09)Chloroplasts are the site of the <em>de novo</em> synthesis of the predominant proportion of fatty acids in plant cells. The growing fatty acid chain is bound to acyl carrier protein (ACP) during synthesis. Acyl-ACP ... -
A role of Alzheimer’s disease-associated γ-secretase in lipid metabolism and lipid droplet formation via LXR activation
Gutierrez, Esteban (2021-06-29)The γ secretase is an intramembrane protease complex, essential for the processing of a wide variety of type-1 membrane proteins. Among these is the amyloid precursor protein (APP), a protein strongly linked to Alzheimer’s ... -
Role of antimicrobial peptides in metabolism and innate immunity in Drosophila melanogaster
Varma, Disha (2014-08-12)“Metabolism” and “Immunity” are two essential, recognized and independent functions of animal kingdom. They have their own biological cycle independent of each other. While metabolism contributes, amongst other things, to ... -
The Role of Apoptosis Inducing Factor In modulating mtDNA copy number
Meyer, Katharina (2015-06-03)Mitochondrial DNA (mtDNA) encodes essential components of the mitochondrial electron transport chain. Depletion and mutations of mtDNA cause mitochondrial dysfunctions resulting in numerous human diseases, including ... -
Role of astrocytic connexins in health and disease
Dublin, Pavel (2012-09-28)Despite of the growing number of studies, the expression pattern as well as the exact functions of astrocytic connexins are not yet fully elucidated. In this study I analyzed the expression pattern and functions of the two ... -
The role of beta arrestin 1 in vascular tone regulation of pulmonary arteries
Lebender, Leonard (2021-09-07)Vascular tone regulation is facilitated by a complex interplay of various constricting and relaxing mechanisms. Excessive vasoconstriction is a prominent symptom of multiple vascular diseases and target of numerous ... -
The role of calcium signaling in plants: from Arabidopsis to barley
Giridhar, Maya (2021-11-22)Ca<sup>2+</sup> is an important intracellular secondary messenger involved in many signal transduction pathways in plants. During abiotic and biotic stresses, specific Ca<sup>2+</sup> signatures are formed within the plant ... -
The role of ceramide synthase 2 in sphingosine-1-phosphate-mediated thymic egress
Rieck, Michael (2017-12-11)A key element for effective adaptive immunity against invading pathogens is an everchanging peripheral TCR repertoire, which requires the constant release of newly formed T cells from the thymus. The process of thymic ... -
The role of cGMP/PKG1 signaling in osteogenic differentiation
Schall, Nadine (2022-02-25)Nitric oxide has important effects on bone cell function. NO stimulates cGMP synthesis, activation of protein kinase G (PKGs) and improves proliferation, differentiation, and survival of bone forming cells. In bone resorbing ... -
The role of Cysteine-rich with EGF-like domains 2 in the maintenance of metabolic homeostasis and regulation of the unfolded protein response
Kern, Paul (2019-12-17)Das Ziel dieser Arbeit war es, die Rolle von Creld2 bei der Aufrechterhaltung der metabolischen Homöostase unter Normalbedingungen und bei der Regulation der UPR unter ER Stressbedingungen zu untersuchen. Metabolische ... -
The role of cytohesins and the ARNO-CNK1 complex in insulin signalling
Sieg, Christian (2018-09-26)The tight regulation of signalling cascades is of crucial importance for organisms in order to react to external stimuli and maintain homeostasis. Insulin signalling is a key metabolic pathway in vertebrates and dysregulation ... -
The role of diacylglycerol acyltransferase 1 in hepatic medium-chain fatty acid metabolism
Wunderling, Klaus (2020-01-28)Fatty acids form a class of important biomolecules, serving as essential elements of lipid molecules. Stored in triacylglycerol (TAG), the main constituent of plant oils and animal fats, they from an inseparable part of ... -
The role of endocannabinoid system in brain aging
Piyanova, Anastasia (2012-07-23)Endocannabinoid system has recently been shown to play a role in brain aging. Mice lacking cannabinoid CB1 receptors (CB1 receptor knockout, Cnr1-/- mice) show signs of accelerated aging specific to the brain and cognitive ... -
The role of endocannabinoid system in neuron-glial communication in the ageing and diseased brain
Ativie, Frank (2017-12-13)The endocannabinoid system has been implicated in the regulation of glial activity and progression of brain ageing. Mice constitutively or specifically lacking the cannabinoid receptor 1 (CB1) on neurons or GABAergic neurons ... -
Role of Endothelin-1 in the Brown Adipose Tissue
Löffler, Stefan Michael Jan (2021-06-22)ET-1 was shown to inhibit adipogenesis in murine mesenchymal stem cells derived from new-born brown adipose tissue in vitro and antagonism of Endothelin-1 (ET-1) signaling at the respective level of the Endothelin-1 receptor ... -
The role of Four-and-a-half LIM domain protein 2 in dendritic cell migration
König, Katharina (2012-01-12)We identified the four-and-a-half LIM domain protein 2 (FHL2) as a novel regulator of CCL19-induced dendritic cell (DC) migration. Initiation of migration is a hallmark of DC function and plays a central role in the induction ... -
The role of GBA2 in controlling locomotor activity
Woeste, Marina Amelie (2018-12-13)Glycosphingolipids are major constituents of cellular membranes, fulfilling both structural and functional roles. Modifications of the basic glycosphingolipid glucosylceramide (GlcCer) result in numerous complex glycosylated ... -
The role of glial calcium changes in animal models of stroke
Rakers, Cordula Marijke (2015-12-04)Ischemic stroke represents one of the leading causes of death and disability. A main characteristic of the early phase of stroke is the spontaneous appearance of peri-infarct depolarizations (PIDs), which are known to ...