The Faculty of Mathematics and Natural Sciences: Browsing Mathematisch-Naturwissenschaftliche Fakultät by Author "Latz, Eicke"
Now showing items 1-11 of 11
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Alternative splicing as a regulatory mechanism of the NLRP3 inflammasome
Hoß, Florian (2019-10-09)The innate immune system relies on germ-line encoded pattern recognition receptors and is critically involved in the early sensing of pathogens and disturbances of cell homeostasis. Upon activation by pathogenic or sterile ... -
Characterization of small molecule inhibitors of the NLRP3 inflammasome
Monks, Brian (2021-08-04)To respond quickly to infection, the innate immune system contains many germline encoded pattern recognition receptors (PRRs) that recognize a myriad of danger signals released by pathogens and damaged tissues. NLRP3 ... -
Fast detection of protein-protein interactions with an automated FRET-based system on the flow cytometer
von Kolontaj, Kerstin (2018-03-12)Although protein-protein interactions play a major role in almost all biological functions, those interactions cannot easily be analysed, especially not on single cell level and with regard to dynamic changes in protein ... -
Identification of novel TAM receptor interacting proteins: Screening for novel ligands
Görgen, Simon (2019-02-07)The TAM receptors TYRO3, AXL, and MER are well characterized for their roles in cell proliferation and survival, phagocytosis, and inhibition of inflammation. The complexities of these TAM receptor responses imply a level ... -
Investigating the molecular mechanism of the anti-inflammatory effects of HDL in macrophages
Labzin, Larisa (2015-03-17)Inflammation is critical for clearing microbial infections, however, excessive or pro-longed inflammation is an underlying component of many disease states, including atherosclerosis. Macrophages recognise sterile or ... -
Molecular Mechanisms of NLRP3 Inflammasome Activation: Involvement of the Leucine-Rich Repeat Domain and Charcot-Leyden Crystals
Rodríguez Alcázar, Juan Francisco (2021-07-29)Chronic inflammation is a major driver of several non-communicable diseases. The cytosolic pattern recognition receptor NLRP3 is involved in the development of many of these diseases, as its activation in innate immune ... -
Platelet-immune cell interactions in inflammation and cancer
Rolfes, Verena (2019-09-10)Platelets are well-known for their role in hemostasis and only more recently, they have also been acknowledged for their immune regulatory roles. Despite being small sized and anucleated, they can respond to inflammatory ... -
Regulation of inflammasome activation: roles for phospholipase C and mitochondria
Próchnicki, Tomasz (2021-08-05)Inflammasomes are protein complexes serving as activation platforms for the protease caspase-1, which leads to a pro-inflammatory type of cell death termed pyroptosis and to maturation and release of the cytokines interleukin- ... -
The role of the miR-17-92 cluster in macrophage driven innate immunity
Stunden, H. James (2018-12-11)Research into miRNA, discovered in 1993, has exploded and revolutionized our understanding of molecular regulation in biological systems. MicroRNAs are now a well established as a regu- latory mechanism of many pathways ... -
Role of the Receptor for Advanced Glycation End-products (RAGE) in the Immune Sensing of Nucleic Acids
Bertheloot, Damien (2016-09-06)Nucleic acid recognition is an important mechanism that enables the innate immune system to detect both microbial infection and tissue damage. To minimize the recognition of self-derived nucleic acids, all nucleic acid ... -
Targeting cholesterol crystals in atherosclerosis with cholesterol solubilizing 2-hydroxypropyl-β-cyclodextrin
Grebe, Alena (2016-12-21)Atherosclerosis is the underlying pathology of cardiovascular diseases (CVDs), the leading cause of deaths worldwide. Elevated blood cholesterol levels have been linked to this slowly progressing inflammatory disease and ...