Mathematisch-Naturwissenschaftliche Fakultät: Auflistung Mathematisch-Naturwissenschaftliche Fakultät nach Autor "Wagner, Karl G."
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Continuous granulation and drying: Building a comprehensive process understanding based on Quality by Design principles
Menth, Judith (2022-01-21)This thesis investigated a complete integrated continuous granulation and drying line including the process units continuous dosing, continuous twin screw wet granulation and continuous fluid bed drying, considering also ... -
In vivo Relevant Drug Product Evaluation by Using the Biphasic Dissolution Assay (BiPHa+)
Denninger, Alexander Peter (2022-06-13)An increasing number of new chemical entities struggled with a very poor solubility in aqueous media. Solubility or the ability to dissolve in intestinal media is obligatory for oral bioavailability. Dealing with this ... -
Innovative Pharmaceutical Stabilization and Formulation Techniques for Protein Drugs
Dauer, Katharina (2023-12-18)Solid protein formulations for peroral, nasal or parenteral administration would significantly improve the therapeutic use, compliance, and stability of protein-based drugs. The aim of this work was to develop, apply, and ... -
Particle engineering for high dose dry powder inhalation of itraconazole
Willmann, Ann-Cathrin (2022-12-05)Itraconazole (ITZ) is considered as first-line therapy against respiratory infections such as allergic bronchopulmonary aspergillosis. Local treatment of these infections is regarded beneficial as it might reduce systemic ... -
Process models for the continuous manufacturing of tablets via direct compression
Kreiser, Marius Johannes (2022-12-08)The modularity of the continuous manufacturing line PCMM is accompanied by a complexity of parameter connections and process dependencies. To develop a holistic understanding of the continuous process, this work examined ... -
Supersaturation and solubilization to enhance the oral bioavailability of poorly soluble drug molecules: A mechanistic understanding of their potential and limitations
López Mármol, Álvaro (2021-07-28)The stabilization of the supersaturated state in solution was in the last few decades identified as a suitable strategy to enhance the oral bioavailability of poorly soluble drug molecules. From this point of view, drug ... -
Twin-screw Melt Granulation as alternative Granulation Strategy
Steffens, Kristina Elena (2021-07-28)Melt granulation is an interesting alternative technique to produce both, immediate and controlled-release final products using twin-screw extruders. The aim of this current work was to gain a deeper understanding of the ...