The Faculty of Mathematics and Natural Sciences: Search
Now showing items 91-100 of 184
Computational Analysis of Structure-Activity Relationships: From Prediction to Visualization Methods
(2012-07-18)
Understanding how structural modifications affect the biological activity of small molecules is one of the central themes in medicinal chemistry. By no means is structure-activity relationship (SAR) analysis a priori ...
Revealing the Mechanism of Thiopeptide Antibiotics at Atomistic Resolution: Implications for Rational Drug Design
(2012-07-18)
For decades drug design has primarily focused on small molecules that bind to well-formed tight binding pockets, such as the catalytic centers of enzymes. Recently, there is increasing interest to design compounds that ...
A Mathematical Model of the Potassium Homeostasis in Saccharomyces cerevisiae
(2012-07-20)
Without potassium, all living cells will die; it has to be present in sufficient amounts for the proper function of most cell types. Disturbances in potassium levels in animal cells result in potentially fatal conditions ...
Characterization of Parathyroid Hormone Receptor 1 in Periodontal Ligament Cells
(2012-07-13)
In addition to the classic catabolic effects, it is now widely accepted that parathyroid hormone (PTH) exerts anabolic effects on bone, when administered intermittently. As a result of the regenerative characteristic, ......
Optimal transport between random measures
(2012-07-17)
We study couplings q• of two equivariant random measures λ• and μ• on a Riemannian manifold (M,d,m). Given a cost function we ask for minimizers of the mean transportation cost per volume. ......
Beschreibung von Molekülen mit unscharfen Deskriptoren
(2012-07-17)
In der vorliegenden Arbeit wurde ein Verfahren zur Analyse von Molekülen auf Grundlage ihrer molekularen Oberfläche und lokalen Werte für physiko-chemische und topografische Eigenschaften entwickelt.
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Non-asymptotic Error Bounds for Sequential MCMC Methods
(2012-07-17)
Sequential MCMC methods are a class of stochastic numerical integration methods for target measures $\mu$ which cannot feasibly be attacked directly with standard MCMC methods due to the presence of multiple well-separated ...
Effect of iron and sulfur on the solubility of highly siderophile elements in silicate melts
(2012-07-13)
An important aspect in highly siderophile element (HSE - Os, Ir, Ru, Rh, Pt, Pd, Re, Au) geochemistry is their solubility in silicate melts. Knowing the solubility of HSE in silicate melts can potentially give insights on ...
Mining the Medical and Patent Literature to Support Healthcare and Pharmacovigilance
(2012-07-18)
Recent advancements in healthcare practices and the increasing use of information technology in the medical domain has lead to the rapid generation of free-text data in forms of scientific articles, e-health records, ...
Holistic Vocabulary Independent Spoken Term Detection
(2012-06-04)
Within this thesis, we aim at designing a loosely coupled holistic system for Spoken Term Detection (STD) on heterogeneous German broadcast data in selected application scenarios. Starting from STD on the 1-best output of ...