The Faculty of Mathematics and Natural Sciences: Search
Now showing items 131-140 of 210
Chromen-4-ones as novel potent and selective ligands for purinoceptor-related class A δ-branch orphan G protein-coupled receptors
(2017-05-15)
bout 100 of the roughly 800 members of the G protein-coupled receptor (GPCR) family are so-called orphan GPCRs whose endogenous ligand is not known or not confirmed yet. As the orphan receptors might qualify ...
A gateway to new physics: direct measurement of the top Yukawa coupling to the Higgs boson
(2017-08-23)
The top quark has the largest Yukawa coupling in the Standard Model, is the main contribution to the Higgs mass $m_H$ corrections and defines the evolution of the Higgs effective potential with the energy, together with ...
Couplings and Kantorovich contractions with explicit rates for diffusions
(2017-09-15)
We consider certain classes of diffusion and McKean-Vlasov processes and provide non-asymptotic quantifications of the longtime behavior using coupling methods. The thesis is divided into three main parts.
In the ...
In the ...
Characterizing Objects in Images using Human Context
(2017-09-01)
Humans have an unmatched capability of interpreting detailed information about existent objects by just looking at an image. Particularly, they can effortlessly perform the following tasks: 1) Localizing various objects ...
Collaborative Authoring of Semantically Structured Multilingual Educational Content
(2017-09-29)
A major obstacle of increasing the efficiency, effectiveness and quality of education is the lack of widely available, accessible, multilingual, timely, engaging and high-quality educational material. The creation and ...
Sorting, missorting and spreading of Tau in neurons studied in microfluidic chambers
(2017-09-04)
Tau is a microtubule-associated protein which plays an important role in stabilizing microtubules (Mandelkow and Mandelkow, 2012). Tau is mainly an axonal protein but it is missorted into the somatodendritic compartment ...
Mesh Refinement Strategies for the Adaptive Isogeometric Method
(2017-09-01)
This thesis introduces four mesh refinement algorithms refine_hb, refine_thb, refine_ts2D and refine_tsnD ...
Design, Synthese und Biologische Testung neuartiger Chalkon-Derivate als ABCG2 Inhibitoren
(2017-04-24)
Multidrug Resistenz (MDR) von Krebszellen, verursacht durch eine gesteigerte Expression von ABC Transportern, zählt zu den Gründen für das Scheitern einer Chemotherapie. Die Entwicklung potenter und selektiver Inhibitoren ...
Investigating the GBA1-dependent regulation of GBA2 activity in Gaucher disease
(2017-08-01)
Glycosphingolipids (GSLs) are a large and heterogeneous class of lipids, whose function is equally versatile and complex. They consist of a membrane anchor, ceramide, and different kinds of sugar head groups. Glucosylceramide ...
Radialgliaähnliche Vorläuferzellen aus pluripotenten Stammzellen: ein stabiles Intermediat zur effizienten Generierung humaner Oligodendrozyten
(2017-09-12)
Als myelinproduzierende Zellen spielen die Oligodendrozyten eine essenzielle Rolle für die Funktionalität des Zentralnervensystems (ZNS). Sie bilden die isolierenden Myelinscheiden der Neurone und garantieren so eine ...