The Faculty of Mathematics and Natural Sciences: Search
Now showing items 31-40 of 217
Rock slope instability in alpine geomorphic systems, Switzerland
(2018-04-26)
Faced with the hazard potential and geomorphic importance of rock slopes adjusting to glacier retreat and current climate warming, the motivation of this dissertation is to increase our systemic and process understanding ...
Investigation of systemic inflammation in aneurysmal subarachnoid hemorrhage (aSAH) and its impact on post-aSAH complications
(2018-05-23)
Aneurysmal subarachnoid hemorrhage (aSAH) is a dreadful disease with overwhelmingly high mortality and morbidity, although it accounts for only 5% of all strokes. Around half of the affectees are destined to death and it ...
The role of guanine nucleotide exchange factors (GEFs) in EGF-receptor signalling: Screening for a small molecule inhibitor of the Rin1-mediated Rab5 activation
(2018-06-04)
The small GTPase Rab5 is a key regulator of early endosomal trafficking. It functions as a molecular switch that can be activated by guanine nucleotide exchange factors (GEFs) and inactivated via hydrolysis of GTP with the ...
Complement-mediated neuronal loss by sialic acid glycocalyx alterations
(2018-04-23)
Every neuronal cell is covered with a dense structure of glycoconjugates, the glycocalyx. Sialic acids form the terminal ends of the glycocalyx and thus, are more accessible for the cellular environment. Microglia, the ...
Hochauflösende Protonen-Transfer-Reaktions-Massenspektrometrie zur Bestimmung des photochemischen Abbaus von grünen Blattduftstoffen
(2018-04-27)
Die globalen Emissionen von biogenen flüchtigen organischen Verbindungen (1089 Tg/y, Guenther et al. [2012]) übersteigen die globalen Emissionen anthropogen Ursprungs (110 Tg/y, Piccot et al. [1992]) um beinahe ......
Searching for Pulsars in Unassociated Fermi-LAT sources
(2018-05-22)
Pulsars have always been under the γ-ray spotlight since the birth of γ-ray astronomy. They were the first sources that were firmly established as γ-ray sources in the 70s. Since then, pulsars have been the prime suspect ...
Regulation of gene expression in specific mouse brain cells during neurodegenerative prion disease
(2018-05-24)
Why neurodegenerative diseases target specific brain regions is poorly understood. We hypothesize that this selective vulnerability is caused by specific brain cells in these regions having unique strategies and capacities ...
Dry granulation via roller compaction: investigation on scale up strategies integrating process parameters and critical material attributes
(2018-05-23)
Granulation processes for solid oral dosage forms are commonly used in the pharmaceutical industry to enhance the quality of the final product, i.e. tablets. Today, roller compaction is one of the most common granulation ...
Propagation of land surface model uncertainties in simulated terrestrial system states
(2018-05-15)
This study demonstrates how vegetation uncertainty propagates in the terrestrial system and how to reduce this uncertainty. Different stomatal conductance equations and different leaf area index input exist for solving ...
Numerical methods in stochastic and two-scale shape optimization
(2018-04-26)
In this thesis, three different models of elastic shape optimization are described. All models use phase fields to describe the elastic shapes and regularize the interface length on some level or scale to control fine-scale ...