Mathematisch-Naturwissenschaftliche Fakultät: Suche
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Handeln in riskanten Umwelten - Überlebenssicherung um welchen Preis?: Das Beispiel der Region Atakora in Nord-Benin
(2021-08-09)
Trotz Naturschutz geht das Artensterben voran und die Klimakrise erreicht fast alle Weltregionen und verursacht aufgrund von Unvorhersehbarkeiten die Destabilisierung von sozialen und ökologischen Räumen. Um einen sicheren ...
The interplay of differentially γ-carboxylated vitamin K dependent proteins constitute variable VKCFD1 phenotypes
(2021-11-18)
Vitamin K dependent coagulation factor deficiency type 1 (VKCFD1) is a rare hereditary bleeding disorder caused by mutations in γ-Glutamyl carboxylase (GGCX). VKCFD1 patients are treated with high dose of vitamin K, ...
Detection of Legionella pneumophila and Pseudomonas aeruginosa and biofilm experiments in four different cooling towers (construction and biocide treatment) and evaluation of IDEXX most probable number methods in industrial water samples
(2021-11-30)
The responsible maintenance of evaporative cooling systems is an essential element in reducing the risk of the environmental dispersion of legionellae and Legionnaires’ disease outbreaks. In Germany, the 42nd Ordinance ......
Rationales Design und Aufbau DNA- und Fluorophor-markierter chemischer Sonden für G-Protein-gekoppelte Rezeptoren
(2021-03-04)
Die vorliegende Dissertation umfasst die Synthese von Wirkstoff-Molekülen sowie fluoreszenzmarkierten und Oligonukleotid-gebundenen Wirkstoffen, die als Sonden zur Untersuchung von G-Protein-gekoppelten Rezeptoren (GPCRs), ...
Synthesis, optimization, and characterization of chromen-4-one and 1,7-phenanthroline derivatives as ligands for the orphan G protein-coupled receptors 35 and 84
(2021-06-21)
G protein-coupled receptors (GPCRs) are ideal drug targets. Their characteristic tissue distribution, marked ligand specificity, and their roles in countless (patho)physiological processes are being exploited by more than ...
Translatome analysis and in vivo Ca2+ imaging of astrocytes in an Alzheimer’s disease mouse model
(2021-03-18)
One of the most prominent hallmarks of Alzheimer’s Disease (AD) is the accumulation of amyloid beta (Abeta) species, which have the tendency to form extracellular insoluble Abeta plaques and induce reactive astrogliosis ...
Regulation of inflammasome activation: roles for phospholipase C and mitochondria
(2021-08-05)
Inflammasomes are protein complexes serving as activation platforms for the protease caspase-1, which leads to a pro-inflammatory type of cell death termed pyroptosis and to maturation and release of the cytokines interleukin- ......
Medicinal chemistry and molecular pharmacology of orphan human Mas-related G protein-coupled receptors X2 and X4 (MRGPRX2 and MRGPRX4)
(2021-10-19)
The MRGPRX protein subfamily comprise rhodopsin-like orphan GPCRs, whose endogenous agonists have not been identified yet. They are exclusively expressed in primates, including humans. All Mas-related GPCRs (MRGPRs) were ...
Supersaturation and solubilization to enhance the oral bioavailability of poorly soluble drug molecules: A mechanistic understanding of their potential and limitations
(2021-07-28)
The stabilization of the supersaturated state in solution was in the last few decades identified as a suitable strategy to enhance the oral bioavailability of poorly soluble drug molecules. From this point of view, drug ...
The chromatin organizer Satb1 regulates the differentiation into CD4+ TH subsets and is essential for the development of TH17 cells
(2021-06-04)
CD4+ T cells play a critical role in host defense and tissue homeostasis. Upon encountering their specific antigen, naive CD4+ T cells can differentiate into the effector T helper (TH) subsets ...