The Faculty of Mathematics and Natural Sciences: Search
Now showing items 11-20 of 38
K-K and π-K Scattering Lengths at Maximal Isospin from Lattice QCD
(2019-08-02)
The current work presents calculations of the elastic scattering length a0 for systems of two Kaons and one pion and one Kaon, respectively. The values for a0 have been obtained from lattice QCD ......
Structural conformational analysis of molecular dynamics of a P-glycoprotein homology model and generated intermediate structures
(2019-10-02)
The major reason for failure of chemotherapy in cancer is multidrug resistance. A mechanism by which human cancers develop multi-drug resistance is over expression of certain ATP-binding cassette (ABC) transporters. ...
Effects of intracranial stimulation and the involvement of the human parahippocampal cortex in perception
(2019-10-04)
How the human brain translates photons hitting the retina into conscious perception remains an open question. Throughout the medial temporal lobe (MTL), there are neurons (called concept cells) that change their firing ...
Pharmacometric approaches for linking pharmacokinetic and pharmacodynamic models of sunitinib and pazopanib with clinical outcome
(2019-07-22)
Aim of this thesis was to build a modeling framework for patients with metastatic renal cell carcinoma (mRCC) treated with two common first-line therapies, sunitinib and pazopanib. Therefore, as part of the European-wide ...
FR900359, an inhibitor of guanine nucleotide dissociation, effectively blunts signaling of GTPase-deficient Gq: mechanism of action and relevance for treating Gq-driven cancers
(2019-08-01)
Uveal melanoma (UM), the most common cancer of the adult eye, is known to have poor prognosis. Over 50% of patients are likely to develop metastasis. In more than 80% of the cases UM is driven by an activating mutation in ...
Impact of ERK signaling and its spatial regulation on cisplatin sensitivity in ovarian cancer cells
(2019-11-08)
The efficiency of the anticancer drug cisplatin in ovarian cancer is often limited by the development of cisplatin resistance. Cisplatin activates a plethora of DNA damage-related signaling pathways, which regulate the ...
Einfluss der tRNA Modifikation i6A37 auf die Translation in Säugern und deren Mitochondrien
(2019-10-17)
Modifizierte Basen in tRNA-Anticodonschleifen üben einen direkten Einfluss auf die Translationsmaschinerie aus. N6-Isopentenyladenosin (i6A) ist die älteste bekannte tRNA-Modifikation. Jedoch war ihre ......
Platelet-immune cell interactions in inflammation and cancer
(2019-09-10)
Platelets are well-known for their role in hemostasis and only more recently, they have also been acknowledged for their immune regulatory roles. Despite being small sized and anucleated, they can respond to inflammatory ...
Application of Sensitive API-Based Indicators and Numerical Simulation Tools to Advance Hot-Melt Extrusion Process Understanding
(2019-09-11)
This dissertation explored the use of active pharmaceutical ingredients (APIs) as indicator substances as well as numerical process simulation to enhance process understanding of hot-melt extrusion (HME) in the pharmaceutical ......
The role of the zinc finger transcription factor Gli3 in murine hindbrain development
(2019-07-15)
The zinc finger transcription factor GLI3 is a downstream component of the Sonic Hedgehog signaling pathway and functions mostly as a transcriptional repressor. GLI3 is required for the proper development of dorsal forebrain, ......
Der Zinkfinger-Transkriptionsfaktor GLI3 ist eine der nachgeschalteten Komponenten des Sonic Hedgehog Signalwegs, und fungiert hauptsächlich als transkriptioneller Repressor. GLI3 ist für die normale Entwicklung des dorsalen ......
Der Zinkfinger-Transkriptionsfaktor GLI3 ist eine der nachgeschalteten Komponenten des Sonic Hedgehog Signalwegs, und fungiert hauptsächlich als transkriptioneller Repressor. GLI3 ist für die normale Entwicklung des dorsalen ......