The Faculty of Mathematics and Natural Sciences: Search
Now showing items 211-220 of 272
Charakterisierung allosterischer Bindungsstellen von P2X4-Rezeptor-Modulatoren
(2017-04-24)
P2X-Rezeptoren stehen aufgrund ihrer Beteiligung an zahlreichen (patho)physiologischen Prozessen wie der Wahrnehmung von Schmerz, entzündlichen Veränderungen oder Krebs als Zielstrukturen für potentielle neue Wirkstoffe ...
Feasibility and Efficacy of a Collaborative Medication Management for Elderly, Multimorbid Patients
(2017-08-29)
Medication Review and Medication Management are new pharmaceutical care services with a strong potential to contribute to patients’ health care outcomes. The aim of this work was to evaluate an interprofessional, collaborative ...
Chromen-4-ones as novel potent and selective ligands for purinoceptor-related class A δ-branch orphan G protein-coupled receptors
(2017-05-15)
bout 100 of the roughly 800 members of the G protein-coupled receptor (GPCR) family are so-called orphan GPCRs whose endogenous ligand is not known or not confirmed yet. As the orphan receptors might qualify ...
Design, Synthese und Biologische Testung neuartiger Chalkon-Derivate als ABCG2 Inhibitoren
(2017-04-24)
Multidrug Resistenz (MDR) von Krebszellen, verursacht durch eine gesteigerte Expression von ABC Transportern, zählt zu den Gründen für das Scheitern einer Chemotherapie. Die Entwicklung potenter und selektiver Inhibitoren ...
Investigations on the synthesis and reactivity of σ3λ3-oxaphosphirane complexes with fluorinated C-substituents
(2017-03-02)
The objective of this PhD work was to synthesize new oxaphosphirane complexes having the triphenylmethyl group bound to phosphorus. These derivatives may possess a higher lability of the P-C exocyclic bond than other ...
Localization of Paramagnetic Metal Ions in Biomolecules ny means of Electron Paramagnetic Resonance
(2017-03-23)
Localization of metal ion binding sites in biomolecules is an important objective in structural biology. Experimental methods that are commonly used to determine the location of metal ions, such as X-ray crystallography ...
Cellular biomechanics in 2D and 3D epithelial model tissues: from keratin intermediate filaments to breast gland in vitro reconstructed basement membranes
(2017-01-24)
The mechanical organization of biological tissue is crucial to the load-transmitting capacity of our bodies, and follows a hierarchical architecture that macroscopically results in organ’s formation and function. At the ......
Molecular Approach toward Gases Absorption by Ionic Liquids
(2017-01-24)
This thesis reports the theoretical studies of gas absorption in complex systems. These systems, namely ionic liquids, are considered to be promising candidates to substitute conventional gas capture systems which violate ...
Synthese, Modellierung und Evaluation supramolekularer 9,9’-Spirobifluoren-Rezeptoren zur Erkennung organischer Ammoniumionen
(2017-09-27)
Diese Dissertation befasst sich mit der experimentellen und quantenchemischen Untersuchung des Bindungsverhaltens supramolekularer 9,9’-Spirobifluoren-Rezeptoren gegenüber verschiedenen Aminosäureestern.
Dazu wurden ...
Dazu wurden ...
Fusogene und endozytotische Liposomen: Vergleichende Untersuchungen zum Wirkstofftransport am Beispiel von Doxorubicin und Aclacinomycin A
(2017-09-21)
Liposomen sind zum Einschleusen von hydrophilen und hydrophoben Molekülen weit verbreitet. Über welchen Mechanismus die Liposomen in Zellen aufgenommen werden, ist entscheidend für die Wirksamkeit der transportierten ...