Mathematisch-Naturwissenschaftliche Fakultät: Suche
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Investigating the GBA1-dependent regulation of GBA2 activity in Gaucher disease
(2017-08-01)
Glycosphingolipids (GSLs) are a large and heterogeneous class of lipids, whose function is equally versatile and complex. They consist of a membrane anchor, ceramide, and different kinds of sugar head groups. Glucosylceramide ...
Radialgliaähnliche Vorläuferzellen aus pluripotenten Stammzellen: ein stabiles Intermediat zur effizienten Generierung humaner Oligodendrozyten
(2017-09-12)
Als myelinproduzierende Zellen spielen die Oligodendrozyten eine essenzielle Rolle für die Funktionalität des Zentralnervensystems (ZNS). Sie bilden die isolierenden Myelinscheiden der Neurone und garantieren so eine ...
Concentration Dependent Ion–Protein Interaction Patterns Underlying Protein Oligomerization Behaviours
(2017-07-27)
Most proteins do not exist as monomers. Instead, proteins assemble into oligomeric structures, which range from small dimers to intermediately sized clusters to large polymers. Oligomerization is driven by protein–protein ...
Regulation der Protein-Homöostase durch das Co-Chaperon Tpr2
(2017-05-15)
Die Erhaltung der Protein-Homöostase ist essentiell für die Funktion einer jeden Zelle. Molekulare Chaperone regulieren dabei ein sensibles Gleichgewicht aus Proteinabbau und -faltung. Neusynthetisierte oder fehlgefaltete ...
Functional regions within a Q/N rich prion domain driving prion replication in the mammalian cytosol
(2017-05-15)
Prions are proteinaceous infectious agents that replicate by recruiting and converting homotypic soluble proteins into growing aggregates. Prions in mammals cause transmissible spongiform encephalopthies and are composed ...
The orphan G protein-coupled receptor GPR17: its pharmacology and function in recombinant and primary cell expression systems
(2017-04-26)
The reconstitution of myelin sheaths, so called remyelination, represents an innovative therapeutic goal in multiple sclerosis (MS), the most common inflammatory-demyelinating disease of the central nervous system (CNS). ...
Functional Characterizations of the Reciprocal Interaction of the Circadian Clock gene Time for coffee (TIC) with Stress and Energy in Arabidopsis
(2017-03-08)
Circadian clocks are important time-environment response mechanism that provide adjustment and adaptation for light, dark, warm, cold or wet, dry altering; some of the altering even caused stresses in plants. The Arabidopsis ...
Functional Modulation of Activated Protein C using DNA-Aptamers
(2017-03-15)
Aptamers are single stranded DNA or RNA oligonucleotides which are able to interact with their designated target molecules with high affinity and specificity. The in-vitro procedure used for aptamer selection from a randomly ...
Systematics, Taxonomy, and Evolution of Urtica L. (Urticaceae)
(2017-04-25)
The systematics of Urtica have puzzled scientists for the past 200 years and no single comprehensive attempt at understanding infrageneric relationships has been published in the past, nor have species delimitations ...
Neuronal Systems Potentially Involved in Autism Spectrum Disorder
(2017-06-01)
Pfn2 is a brain specific actin binding protein involved in actin dynamics. The Pfn2 knock-out mouse model shows an autistic-like phenotype with all of the features commonly reported in autism patients such as social and ......