The Faculty of Mathematics and Natural Sciences: Search
Now showing items 471-480 of 583
The role of Cysteine-rich with EGF-like domains 2 in the maintenance of metabolic homeostasis and regulation of the unfolded protein response
(2019-12-17)
Das Ziel dieser Arbeit war es, die Rolle von Creld2 bei der Aufrechterhaltung der metabolischen Homöostase unter Normalbedingungen und bei der Regulation der UPR unter ER Stressbedingungen zu untersuchen. Metabolische ...
Characterization of the functional role of the Cystein-rich with EGF-like domains (Creld) protein in mitochondrial quality control in Drosophila melanogaster
(2019-08-01)
Cystein-rich with EGF-like domains (Creld) proteins belong to a protein family conserved between species. The mammalian genome contains two Creld genes. Unraveling the function of mammalian Creld proteins has been tried ...
Effects of intracranial stimulation and the involvement of the human parahippocampal cortex in perception
(2019-10-04)
How the human brain translates photons hitting the retina into conscious perception remains an open question. Throughout the medial temporal lobe (MTL), there are neurons (called concept cells) that change their firing ...
Alternative splicing as a regulatory mechanism of the NLRP3 inflammasome
(2019-10-09)
The innate immune system relies on germ-line encoded pattern recognition receptors and is critically involved in the early sensing of pathogens and disturbances of cell homeostasis. Upon activation by pathogenic or sterile ...
Cutin, wax and stomatal mutants of Arabidopsis thaliana: chemical and physiological analysis of the leaf barrier properties
(2019-10-08)
Stomatal pores and the cuticular membrane are the two major key elements to regulate the gas exchange and water balance of plants. The hydrophobic cuticle covers all aerial parts of plants in their primary developmental ......
The plesiosaur: remarkable morphology, histology, and physiology
(2019-07-04)
In this dissertation, contributions to understanding the morphology, histology, and physiology of plesiosaurs, a major group of marine reptiles from the Age of Dinosaurs, are presented. By using comparative methods and new ......
Expression and Function of ErbB4 Splice Variants in the Central Nervous System
(2019-07-18)
Neuregulins and their cognate neuronal receptor tyrosine kinase ErbB4 (avian erythroblastosis virus oncogene B4) are genetically linked with an increased risk for schizophrenia. NRG/ErbB4 signaling regulates neurodevelopment, ......
Neureguline und ihr neuronaler Tyrosinkinaserezeptor ErbB4 (avian erythroblastosis virus oncogene B4) sind genetisch mit einem erhöhtem Risiko für Schizophrenie assoziiert. NRG/ErbB4 Signalübertragung reguliert unter anderem ......
Neureguline und ihr neuronaler Tyrosinkinaserezeptor ErbB4 (avian erythroblastosis virus oncogene B4) sind genetisch mit einem erhöhtem Risiko für Schizophrenie assoziiert. NRG/ErbB4 Signalübertragung reguliert unter anderem ......
FR900359, an inhibitor of guanine nucleotide dissociation, effectively blunts signaling of GTPase-deficient Gq: mechanism of action and relevance for treating Gq-driven cancers
(2019-08-01)
Uveal melanoma (UM), the most common cancer of the adult eye, is known to have poor prognosis. Over 50% of patients are likely to develop metastasis. In more than 80% of the cases UM is driven by an activating mutation in ...
Impact of ERK signaling and its spatial regulation on cisplatin sensitivity in ovarian cancer cells
(2019-11-08)
The efficiency of the anticancer drug cisplatin in ovarian cancer is often limited by the development of cisplatin resistance. Cisplatin activates a plethora of DNA damage-related signaling pathways, which regulate the ...
Application and Development of Mass Spectrometry-based Approaches to Investigate the Regulation of Lysosomal-associated Proteins by Phosphorylation
(2019-11-12)
Phosphorylation is one of the most abundant and best studied posttranslational modifications in mammalian cells and refers to the addition of a phosphate group to an amino acid residue of a protein. Phosphorylation can ...