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Predicting Rules for Cancer Subtype Classification using Grammar-Based Genetic Programming on various Genomic Data Types
(2018-03-12)
With the advent of high-throughput methods more genomic data then ever has been generated during the past decade. As these technologies remain cost intensive and not worthwhile for every research group, databases, such as ...
Xenosialitis modulates the function of the Alzheimer’s disease associated SIGLEC3 in human THP1 macrophages
(2018-03-26)
Chronic inflammation is an undisputed feature of late onset Alzheimer’s disease (LOAD). Activated microglia,found around amyloid beta (Aβ) plaques are implicated as the source of inflammation. However they are incapable ...
Supra-molecular structures at the cytoplasmic periphery of the plasma membrane
(2018-02-15)
The self-assembly of biomolecules into supra-molecular structures is an important principle underlying cellular organization. These structures define spatial environments for diverse biological processes. In particular, ...
Alternatives Spleißen von BAG6 verändert die Zytoskelett-Architektur und die epithelial-mesenchymale- Transition in humanen Zellen
(2018-10-12)
Das menschliche Genom gewinnt durch alternatives Spleißen an zellulärer Proteinkomplexi-tät. Für mehrere Vertreter der BAG-Proteinfamilie sind bisher Spleißvarianten bekannt, die sich in ihrer Wirkung auf die zelluläre ...
The role of cytohesins and the ARNO-CNK1 complex in insulin signalling
(2018-09-26)
The tight regulation of signalling cascades is of crucial importance for organisms in order to react to external stimuli and maintain homeostasis. Insulin signalling is a key metabolic pathway in vertebrates and dysregulation ......
Ectopic expression of the sialic acid modifying enzyme CMAH in human THP1 macrophages
(2018-09-03)
Throughout evolutionary processes, organisms gain or lose functions because of emerging mutations. The frameshift mutation emerged in the human CMAH gene is one of these loss of function mutations and it caused the human ...
The role of GBA2 in controlling locomotor activity
(2018-12-13)
Glycosphingolipids are major constituents of cellular membranes, fulfilling both structural and functional roles. Modifications of the basic glycosphingolipid glucosylceramide (GlcCer) result in numerous complex glycosylated ...
Deciphering the role of the deubiquitinating enzyme Ataxin-3 in transcriptional regulation and the cellular response to stress
(2018-12-19)
Ataxin-3 (ATXN3), the disease-causing protein for Machado Joseph Disease (MJD) is functionally involved in the protein quality control and transcriptional regulation of various genes. Recent data suggest that either ...
Mechanisms of memory consolidation: Analyzing the coordinated activity of concept neurons in the human medial temporal lobe during waking and sleep
(2018-12-11)
The aim of this thesis is to investigate the role of human concept neurons in memory consolidation during sleep. Memory consolidation is a process by which memories initially dependent on the hippocampus are transferred ...
Introduction of crop rotation and rice straw application in a former flooded rice system and their impact on the microbial community in bulk soil and the rhizosphere of Zea mays
(2018-12-13)
Rice is one of the most important staple foods The constant flooding of rice fields results in anoxic conditions in soil, providing an optimal habitat for methane producing Archaea. The produced methane is the main substrate ...