Mathematisch-Naturwissenschaftliche Fakultät: Suche
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Dynamics of group II introns in plant mitogenomes and rickettsial DNA invasions in the mitogenome of Haplopteris ensiformis
(2023-07-27)
The complexity of mitochondrial genomes (mtDNA) in vascular plants is well-known, with factors such as repetitive sequences, variable structural organization, gene synteny decline, high intron content, and RNA editing ...
The Effects of Maternal Obesity on the Innate Immune System: Developmental Programming of Kupffer Cells
(2023-03-29)
The global epidemic of obesity has led to an increasing number of obese women in childbearing age. It is now understood that maternal obesity has harmful consequences on fetal and adult health. The underlying mechanism of ...
Mechanical strain influence on functional signaling of neurons in vitro
(2023-02-22)
Neuronal cells are embedded in the soft brain tissue and are protected by the thick meninges, as well as the rigid skull bones. Despite being highly sensitive and vastly protected, neurons are prone to internal and external ...
Inhibition of heterotrimeric Gs proteins by FR900359 - more than a simple transfer of the inhibitor binding site
(2023-03-07)
A plethora of vital functions of the human body, including blood pressure, cell proliferation and metabolism are regulated by G protein-mediated signaling cascades. These cascades form a complex network of cause and effect ...
Investigating pathomechanisms underlying malformations of human cortical development
(2023-06-15)
During human development the brain has to form a complex neuronal network requiring a well-orchestrated sequence of neurogenesis, neuronal migration and correct positioning within cortical layers followed by synaptogenesis. ...
Complement receptors 3 and 4 in kidney diseases
(2023-12-11)
CR3 and CR4 are among the most abundant molecules on the cell surface of DCs, monocytes/macrophages, and PMNs. Both integrins recognize common ligands among which are iC3b, ICAM-1, and fibrinogen. iC3b is generated as a ......
Investigating the effects of sphingosine-1-phosphate lyase (SGPL1) ablation in mouse embryonic fibroblasts and primary astrocytes
(2023-09-13)
Sphingosine-1-phosphate (S1P) is a bioactive lipid that plays a crucial role in various fundamental processes, including cellular proliferation, survival, migration, as well as inflammation. Additionally, it has been ......
The Synaptic Basis of Binocular Alignment and its Development in Ferret Primary Visual Cortex
(2023-12-01)
The brain integrates information from a myriad of external stimuli to generate a rich but consistent representation of the world and instruct behavior. For coherent binocular vision, signals from both eyes need to be ...
Cryo-EM structures of the human NLRP3 inflammasome
(2023-11-20)
NLRP3 is an intracellular sensor protein whose activation by a broad spectrum of exogenous and endogenous stimuli leads to inflammasome formation and pyroptosis. The mechanisms leading to NLRP3 activation and the way how ...
Characterization of the immune system-drug interactions during anti-filarial treatment in the Litomosoides sigmodontis mouse model
(2024-01-03)
Filarial nematodes can cause debilitating diseases such as lymphatic filariasis and onchocerciasis. Both diseases are included in the list of neglected tropical diseases as defined by the World Health Organization (WHO) ......