Mathematisch-Naturwissenschaftliche Fakultät: Suche
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Metabolites of bacteria isolated from marine environments: chemistry and bioactivities
(2018-04-19)
Roseovarius oyster disease (ROD) is a bacterial-induced infection and causes major problems in oyster aquaculture. Bacteria of the genus Labrenzia have been proposed as protective agents against ROD. The here investigated ...
Complement-mediated neuronal loss by sialic acid glycocalyx alterations
(2018-04-23)
Every neuronal cell is covered with a dense structure of glycoconjugates, the glycocalyx. Sialic acids form the terminal ends of the glycocalyx and thus, are more accessible for the cellular environment. Microglia, the ...
Characterization of the structural-functional impact of heterozygous missense mutations in genes of the blood coagulation factor XIII that cause mild Factor XIII deficiency
(2018-01-04)
The coagulation Factor XIII is a key player in hemostasis that is responsible for the last step of the coagulation cascade in which it covalently cross-links preformed fibrin clots to make them resistant to premature ......
The role of the endocannabinoid receptor CB2 in a mouse model of Alzheimer's disease
(2018-09-26)
Over the past years, an important role of the cannabinoid receptor 2 (CB2) has been implicated in several neurological and immunological conditions, such as experimental autoimmune encephalitis, stroke, memory, neuropathic ......
Untersuchungen zum Metabolismus und Nachweisfenster von γ-Hydroxybuttersäure in biologischem Material
(2018-03-19)
In dieser Arbeit wurden interdisziplinäre Untersuchungen durchgeführt, um die Nachweisbarkeitsdauer nach einer Gamma-Hydroxybuttersäure-(GHB)-Gabe in biologischen Matrices zu verlängern. Es sollten biologische Marker ...
Fast detection of protein-protein interactions with an automated FRET-based system on the flow cytometer
(2018-03-12)
Although protein-protein interactions play a major role in almost all biological functions, those interactions cannot easily be analysed, especially not on single cell level and with regard to dynamic changes in protein ...
Lipide als Transport- und Signalmoleküle: Untersuchungen in Makrophagen und Neuronen
(2018-04-17)
Lipide haben einen großen Anwendungsbereich und speziell in der Biochemie des lebenden Organismus wichtige Funktionen. Neben ihrer hauptsächlichen Funktion als Energiespeicher und Strukturkomponenten der Zellmembranen ...
The importance of endogenous opioids in feeding behavior
(2018-03-14)
Endogenous opioids are involved in a broadly distributed neural network regulating eating behavior. Opioid transmission has long been implicated in controlling hedonic and homeostatic feeding as well as regulating body ......
Functional cooperation of Toll-like receptor signaling and the high-affinity receptor for IgE, FcεRI, on human Langerhans cells
(2018-01-15)
Atopic dermatitis (AD) is a multifactorial severe skin disease with increasing incidence in western countries. In the disease, Langerhans cells (LC) play a pivotal role in bridging innate and adaptive immunity through ......
The endophytic fungus Stemphylium globuliferum – secondary metabolites and biological activities
(2018-01-22)
Fungi are a tremendous source of pharmaceutically significant compounds, e.g. the life saving immunosuppressant drug mycophenolic acid. The current project focused on the investigation of the mold fungus Stemphylium ......