The Faculty of Mathematics and Natural Sciences: Search
Now showing items 141-150 of 159
The impact of dendritic calcium control on interneurons function within the hippocampal circuit
(2018-05-11)
In the past few decades, dendritic integration has been extensively studied in hippocampal excitatory cells (for review see Stuart and Spruston 2015). However, much less effort has been put into understanding inhibitory ...
Predicting Rules for Cancer Subtype Classification using Grammar-Based Genetic Programming on various Genomic Data Types
(2018-03-12)
With the advent of high-throughput methods more genomic data then ever has been generated during the past decade. As these technologies remain cost intensive and not worthwhile for every research group, databases, such as ...
Xenosialitis modulates the function of the Alzheimer’s disease associated SIGLEC3 in human THP1 macrophages
(2018-03-26)
Chronic inflammation is an undisputed feature of late onset Alzheimer’s disease (LOAD). Activated microglia,found around amyloid beta (Aβ) plaques are implicated as the source of inflammation. However they are incapable ...
Mechanisms of memory consolidation: Analyzing the coordinated activity of concept neurons in the human medial temporal lobe during waking and sleep
(2018-12-11)
The aim of this thesis is to investigate the role of human concept neurons in memory consolidation during sleep. Memory consolidation is a process by which memories initially dependent on the hippocampus are transferred ...
Binding of cytohesin 2 to the plasma membrane and its relationship with the EGFR
(2018-11-06)
Eukaryotic cells are compartmentalized by lipid membranes to achieve the spatial separation of biological processes and signaling pathways. Controlled trafficking of proteins between these compartments as well as the ...
Role of the cannabinoid receptor 2 in the development of surgical neuropathic pain
(2018-12-12)
When normal nociceptive pain becomes chronic, it loses its protective function and causes a general pain hypersensitivity. Neuropathic pain is one type of chronic pain, which is caused by various diseases or physical injury ...
Influence of the St John´s wort extract Ze117 and selected ingredients on membrane fluidity and phospholipid composition in rat C6 glioblastoma cells
(2018-10-31)
Chronic stress has been recognized to represent a key factor for the development of depression. Among others cortisol has been described to mediate an adaptive effect on plasma membrane fluidity which may affect signal ...
Investigation of Multipotent Neural Progenitor Cell to Oligodendrocyte Differentiation including the Transcriptional Activator Protein Pur-alpha by Quantitative Proteomics
(2019-02-26)
Oligodendrocytes are neuroglial cells, localized in the white matter of the central nervous system. They develop from neural stem cells (NSCs), which produce, among others, migrating and proliferating oligodendrocyte ...
Functional roles of the chemokine CCL17 in skin and brain immunity
(2019-02-04)
The chemokines CCL17 and CCL22 represent ligands of CCR4 and are mainly produced by dendritic cells (DCs) and macrophages (Mφs) in the immune system. CCL17 was found to promote various inflammatory and allergic diseases, ......
Funktionen des Chemokins CCL17 im Immunsystem der Haut und des Gehirns
Die Chemokine CCL17 und CCL22 sind Liganden von CCR4 und werden hauptsächlich von dendritischen Zellen (DCs) und Makrophagen ......
Funktionen des Chemokins CCL17 im Immunsystem der Haut und des Gehirns
Die Chemokine CCL17 und CCL22 sind Liganden von CCR4 und werden hauptsächlich von dendritischen Zellen (DCs) und Makrophagen ......
Untersuchung von adenosinergen Regulatorproteinen der zirkadianen Rhythmik im Gehirn der Ratte und deren Veränderungen durch Schlafentzug und chronische Koffeineinnahme
(2019-03-07)
Der Neuromodulator Adenosin stellt eine der bedeutendsten schlafregulierenden Substanzen für die Steuerung des Einschlafprozesses dar. Es konnte gezeigt werden, dass Adenosin seine schlafinduzierende Wirkung vorwiegend ...