The Faculty of Mathematics and Natural Sciences: Search
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Receptor-mediated activation and pharmacological inhibition of heterotrimeric G proteins
(2022-11-14)
Heterotrimeric guanine-nucleotide binding proteins (G proteins) are key signal transducers in animal and human cells, where they forward signals transmitted by active G protein-coupled receptors (GPCRs) and trigger ...
Irreversible Antagonists for the Adenosine A2B Receptor
(2022-06-13)
Blockade of the adenosine A2B receptor (A2BAR) represents a potential novel strategy for the immunotherapy of cancer. In the present study, we designed, synthesized, and characterized irreversible A2BAR antagonists based ...