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Design, Synthesis and Structure-Activity-Relationships of Potent Mas-Related G Protein-Coupled Receptor X (MRGPRX) Modulators
(2021-04-12)
The G protein-coupled receptor (GPCR) superfamily with more than 800 members is one of the most important target classes for drug development. After an agonist binds to the receptor, it induces a conformational change ......
EBI2 is a negative modulator of adipose tissue activity
(2020-08-17)
Weight-related diseases are common and often fatal conditions characterized by an imbalance between energy intake and energy expenditure. Obesity and weight gain related diseases such as type 2-diabetes have reached in the ...
The role of Sphingosine-1-phosphate receptors in adipocytes and adipose tissues
(2021-01-19)
Obesity is a worldwide health issue with increasing numbers of patients every year. Moreover, the prevalence of obesity gives rise to related cardiovascular diseases and various other comorbidities influencing quality of ...
The role of GPR111 in adipose tissue
(2021-05-21)
Due to obesity pandemic and limited therapeutic approaches, novel targets of pharmaceutical treatments are urgently needed. AT as a very important metabolic organ is an attractive target for combating obesity and obesity ......
Inhibition of heterotrimeric Gs proteins by FR900359 - more than a simple transfer of the inhibitor binding site
(2023-03-07)
A plethora of vital functions of the human body, including blood pressure, cell proliferation and metabolism are regulated by G protein-mediated signaling cascades. These cascades form a complex network of cause and effect ...