Mathematisch-Naturwissenschaftliche Fakultät: Mathematisch-Naturwissenschaftliche Fakultät: Neuzugänge
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Analysing the Role of CYFIP1 for Mouse Central Nervous System Development Using a Conditional Knockout System
(2023-10-09)The development of the central nervous system (CNS) is a tightly spatiotemporal-regulated process with critical morphogenetic changes, each involving cytoskeletal dynamics. Tight regulation of actin polymerisation, ... -
Towards a measurement of the tHq process in channels with hadronic tau lepton decays
(2023-10-05)This thesis presents the first study to find events of the rare tHq process with ATLAS data in channels with hadronically decaying τ. A baseline framework is developed to select as many signal events as possible in ... -
Tool Compounds to Study Proteolytic Events: Development of von Hippel-Lindau (VHL) Ligands and Combinatorial Generation of Serine Protease Inhibitors
(2023-10-04)Among other principles of regulation, protein functions are controlled by the intracellular or extracellular proteolytic activity of proteases. Proteolysis is a process in which proteins are cleaved, leading to activation ... -
Theoretical and Practical Aspects of Finite Closure Systems for Mining and Learning
(2023-10-04)This thesis investigates the potential and limitations of different adaptations of half-space separations in ordinary Euclidean spaces, one of the most popular paradigms in machine learning, to abstract finite closure ... -
Dry powder inhaler: Interaction between drug particles and the device
(2023-09-28)Dry powder inhalers (DPIs) are delivery devices used to administer the required medication to the patient. Since formulation development has always played an important role, the first study compared the traditional formulation ... -
Fate-Mapping of Yolk Sac-Derived Macrophages
(2023-08-29)To better understand the distinct functions of yolk-sac-derived tissue-resident macrophages (TRMs) and bone-marrow-derived macrophages in homeostasis and disease, it is important to trace the ontogeny of these cells. The ... -
Profilin 1 and profilin 2-dependent actin dynamics shape neuronal morphology and are involved in brain development
(2023-09-27)The actin cytoskeleton is an important structure at the synaptic terminals and controls key parameters in synaptic physiology and plasticity. Actin binding proteins (ABPs) regulate cytoskeletal remodeling and actin dynamics ... -
Fate-Mapping of Hematopoietic Stem Cell-Derived Macrophages
(2023-08-29)Macrophages are cells of the innate immune system, which contribute to the maintenance of tissue homeostasis and form the first line of defense against pathogens. Tissue-resident macrophages that originate from ... -
Calocedrus decurrens (Torrey) Florin und Austrocedrus chilensis (D. Don) Pic. Serm. & Bizzarri: Ein pflanzengeographischer und ökologischer Vergleich zweier Reliktconiferen in den nord- und südamerikanischen Winterregen-Subtropen
(2008)Der bihemispärische, ökologische und pflanzengeographische Vergleich von Calocedrus decurrens (Torrey) Florin und Austrocedrus chilensis (D. Don) Pic. Serm. & Bizzarri in den meridionalen Kordillerenlandschaften der nord- ... -
Computational Modeling of Complex Chemical Transformations in Homogeneous Catalysis
(2023-09-18)Catalysis is involved in most manufactured products and hence it is highly important for supplying the society with energy, food, pharmaceuticals and other goods. In recent years, increasing attention has been paid to the ... -
Modularity of special motives of rank four associated with Calabi-Yau threefolds
(2023-09-18)In this thesis, we study modularity properties of pure motives and mixed period matrices of rank four. The pure motives that we consider are associated with Calabi-Yau threefolds, while the mixed period matrices are ... -
Advancing Knowledge-Enhanced Conversational Systems Leveraging Language Models
(2023-09-18)Large language models empowering recent conversational systems such as Alexa and Siri require external knowledge to generate informative and accurate dialogues. The knowledge may be provided in structured or unstructured ... -
Diastereoselektive Titanocen(III)-Katalyse – Synthese benzylischer 1,3-Dioxolane und 1,3-Oxazolidine
(2023-09-14)Entwickelt wurde eine atomökonomische Titanocen(III)-katalysierte Reaktion, die ausgehend von Benzylethern und Benzylaminen die Synthese benzylischer 1,3-Dioxolane und 1,3-Oxazolidine in moderaten bis exzellenten Ausbeuten ... -
K-Theorie adischer Räume
(2023-09-13)In dieser Arbeit formulieren wir die Grundlagen der <em>K</em>-Theorie im Kontext der adischen Geometrie unter Verwendung des Formalismus der verdichteten Mathematik und der Ergebnisse von Efimov über lokalisierende ... -
Investigating the effects of sphingosine-1-phosphate lyase (SGPL1) ablation in mouse embryonic fibroblasts and primary astrocytes
(2023-09-13)Sphingosine-1-phosphate (S1P) is a bioactive lipid that plays a crucial role in various fundamental processes, including cellular proliferation, survival, migration, as well as inflammation. Additionally, it has been ... -
Establishment of a Split-Combine Cell-SELEX method for Identification of Nucleobase-Modified Aptamers with Specific Binding to Androgen-independent Prostate Cancer Cells
(2023-09-11)Prostate cancer is the most commonly diagnosed malignancy and the second leading cause of cancer-related mortality in men in the United States. Current therapies, such as chemotherapy, radiotherapy, and photothermal therapy, ... -
Ultra-high field NMR spectroscopy of GABA in the human brain
(2023-08-31)Magnetic resonance imaging (MRI) is a non-invasive and radiation-free imaging method that has been utilized in medicine for decades. Using magnetic fields, the nuclear spins within the tissue are perturbed, and the resulting ... -
Studying Conformational Changes of Biomolecules with Spatiotemporal Resolution and in cell using Pulsed Dipolar EPR Spectroscopy
(2023-08-29)The function of biomolecules is closely linked with their structure and dynamics. Furthermore, the interconversion of different conformations of a biomolecule determines its activity and is vital for biomolecular processes. ... -
Aluminum Stress on Suberin Biosynthesis in Barley (Hordeum vulgare) Roots
(2023-08-29)Aluminum (Al) toxicity is a major factor inhibiting plant growth in acidic soils worldwide, and the root barrier formed by suberized cells is an important mechanism for plants to resist environmental stress. The aim of ... -
Temporal Action Segmentation: Weak Supervision and Efficiency
(2023-08-24)Action segmentation deals with the temporal understanding of actions that occur in an untrimmed video. The output of action segmentation is an action label for each frame of the input video. This task has recently received ...
