Publikationen: Browsing Publikationen by Issue Date
Now showing items 1-4 of 4
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Irreversible Antagonists for the Adenosine A2B Receptor
(2022-06-13)Blockade of the adenosine A2B receptor (A2BAR) represents a potential novel strategy for the immunotherapy of cancer. In the present study, we designed, synthesized, and characterized irreversible A2BAR antagonists based ... -
Structure-affinity and structure-residence time relationships of macrocyclic Gαq protein inhibitors
(2023-04-21)The macrocyclic depsipeptides YM-254890 (YM) and FR900359 (FR) are potent inhibitors of Gα<sub>q/11</sub> proteins. They are important pharmacological tools and have potential as therapeutic drugs. The hydrogenated, ... -
A Systematic Database Approach to Identify Companion Diagnostic Testing in Clinical Trials under the New In Vitro Diagnostic Medical Devices Regulation
(2023-06-12)The European Union In Vitro Diagnostic Medical Devices Regulation (EU) 2017/746 (IVDR) introduces companion diagnostics (CDx) as a new legal term. CDx are applied in combination with a medicinal product to identify patient ... -
Development of the first geldanamycin-based HSP90 degraders
(2023-06-28)Despite the early clinical promise, adverse events such as acquired resistance and dose-limiting toxicities have barred the widespread use of HSP90 inhibitors as anticancer drugs. A new approach involving proteolysis-targeting ...
