Browsing by Author "Imhof, Diana"
Now showing items 1-18 of 18
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Biochemical characterization, regulation, and inhibition of human transcription kinases CDK12 and CDK13 and human cell cycle-related kinase CDK14
Dust, Sofia (2019-11-27)The transcription process is the first step in the molecular information flow from genome to proteome. In eukaryotes, the RNA polymerase II (RNAPII) transcribes genes that code for proteins by synthesizing pre-mature ... -
Bridging between data and knowledge: New ways to better understand Alzheimer's Disease and Type 2 Diabetes comorbidity
Karki, Reagon (2021-06-15)The holistic understanding of biological phenomena enabled by systems biology forms the basis of current research. As opposed to the principle of classical biology where behavior of a biological system is explained by ... -
Contextualizing and interpreting biological data with pathway knowledge and network algorithms
Mubeen, Sarah (2023-02-07)Elucidating the mechanisms which give rise to unique biological functions is a major goal of human biology. Vast quantities of biological data that have been amassed can aid us in understanding these mechanisms, such as ... -
In Silico Facets of Biochemical Research: Accounts from Protein Folding and Protein-Ligand Interaction Studies
Paul George, Ajay Abisheck (2020-09-04)Exponential advancements in computer technology over the last five decades have ubiquitously benefited science and humanity as a whole. Consequent beneficiaries of this surge of computational power include all subfields ... -
Functional characterization of Gαi/s proteins and modulation of their activity by linear and cyclic peptides
Pepanian, Anna (2024-01-30)Heterotrimeric Gαβγ (guanine nucleotide-binding) proteins serve as molecular switches to activate (“switch on”) or inactivate (“switch off”) diverse intracellular signaling cascades in response to stimulated G protein-coupled ... -
Functional Modulation of Activated Protein C using DNA-Aptamers
Shahidi Hamedani, Nasim (2017-03-15)Aptamers are single stranded DNA or RNA oligonucleotides which are able to interact with their designated target molecules with high affinity and specificity. The in-vitro procedure used for aptamer selection from a randomly ... -
Histidine and Tyrosine-based Heme-binding Motifs for the Prediction of Heme-Regulated Proteins
Schmalohr, Benjamin Franz (2021-06-01)The versatile molecule heme (iron protoporphyrin IX) fulfils numerous vital functions as a part of hemoproteins, such as hemoglobin and cytochromes, in which it is essential for oxygen transport, electron transport, and ... -
Influence of disulfide-bonds on structural and functional properties of peptides and proteins - Case studies on FXIIIa inhibitor tridegin and µ-conotoxin PIIIA
Schmitz, Thomas (2021-05-28)Disulfide-bonded peptides have been studied for many decades serving as tools to investigate various biochemical pathways as well as lead structures for drug development for numerous diseases. Among these, the most fatal ... -
Influence of the Conformation of Conotoxins on their Bioactivity
Heimer, Pascal (2017-12-14)In the last decade peptides filled the gap between small molecule drugs and biologics as therapeutics. A rich source of such peptides represents the venom of different animals evolved over millions of years. Conotoxins are ... -
The interplay of differentially γ-carboxylated vitamin K dependent proteins constitute variable VKCFD1 phenotypes
Ghosh, Suvoshree (2021-11-18)Vitamin K dependent coagulation factor deficiency type 1 (VKCFD1) is a rare hereditary bleeding disorder caused by mutations in γ-Glutamyl carboxylase (GGCX). VKCFD1 patients are treated with high dose of vitamin K, ... -
Investigation of the procoagulant role of labile heme under hemolytic conditions
Hopp, Marie-Therese (2021-07-19)Severe intravascular hemolysis leads to the excessive release of labile heme into the vascular compartment, thereby overwhelming the heme-binding capacity of the protective heme- scavenging system. As a consequence, labile ... -
Ionic liquids as novel reaction media for the chemical synthesis of peptides
Chen, Ming (2016-12-09)To seek the best solvent in which the peptide can dissolve is usually a serious challenge in peptide chemical synthesis. Ionic liquids, which are liquid below 100 °C, or even at room temperature, showed an outstanding ... -
Modulation der Gαi1/s-Proteinaktivität durch lineare und makrozyklische Peptide
Nubbemeyer, Britta (2021-07-08)Die vorliegende Dissertation beschäftigt sich mit der Identifizierung und Charakterisierung von peptidischen Modulatoren für die Gαi/s-Proteinaktivität. Die Ga-Untereinheit heterotrimerer G-Proteine ist eine bedeutende ... -
Proteomische Funktionsanalyse humanbiologischer Systeme mittels chemisch modifizierter Proteine
Reinartz, Markus (2016-04-18)Das humane Proteom unterliegt gegenüber dem eher statischen Genom einem kontinuierlichen Auf- und Abbau. Diese Dynamik zeigt sich durch ein mehrschichtiges Muster an Protein-Protein Interaktionen.<br /> Im ersten Teil ... -
Structural and functional characterization of human coagulation factor XIII
Singh, Sneha (2020-06-02)The formation of a fibrin clot in blood plasma is a two-step event which involves formation of a “primary clot” comprising of fibrin polymers by from fibrin monomers under the action of thrombin and subsequently the ... -
Studien zur oxidativen Faltung des Faktor-XIIIa-Inhibitors Tridegin
Bäuml, Charlotte Anneke (2020-11-16)Diese Dissertation beschäftigt sich mit der umfassenden Charakterisierung des Naturstoffs Tridegin. Dieses cysteinreiche, 66 Aminosäuren lange Peptid ist ein spezifischer Inhibitor des letzten Schrittes der Blutgerinnungskaskade, ... -
Targeting the Final Step of Blood Coagulation: Structure-Activity-Relationship Studies on the Factor XIIIa Inhibitor Tridegin
Böhm, Miriam (2015-09-23)The prophylaxis and therapy of thrombotic diseases is one of the major columns supporting our continuously increasing life expectancy and health. The transglutaminase factor XIIIa (FXIIIa), which is part of the blood ... -
Transient Heme-Protein Interactions: Structural and Functional Studies on Interleukin-36α and Amyloid-β
Wißbrock, Amelie (2020-08-25)The porphyrin heme is primarily known as a pivotal blood component. As functional part of hemoglobin, heme is responsible for the blood’s vibrant red color and enables the transport of oxygen within the body. Moreover, ...