Browsing by Subject "G protein-coupled receptor"
Now showing items 1-4 of 4
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Elucidating agonist-induced signaling patterns of human G protein-coupled receptor GPR17 and uncovering pranlukast as a biased mixed agonist-antagonist at GPR17
(2011-11-15)The progress of human genome sequencing has revealed the existence of several hundred orphan G protein-coupled receptors (GPCRs), whose endogenous ligands are not yet identified, thus their deorphanization and characterization ... -
Identification, optimization and characterization of pharmacological tools for the cannabinoidactivated orphan G protein-coupled receptor GPR18 and related receptors
(2017-12-21)Cannabinoid receptors comprise two classical subtypes, CB<sub>1</sub> and CB<sub>2</sub>, which belong to the large family of G protein-coupled receptors (GPCRs). They are the major targets of cannabinoids such as ... -
Irreversible Antagonists for the Adenosine A2B Receptor
(2022-06-13)Blockade of the adenosine A2B receptor (A2BAR) represents a potential novel strategy for the immunotherapy of cancer. In the present study, we designed, synthesized, and characterized irreversible A2BAR antagonists based ... -
Synthesis of P2Y12 receptor antagonists as therapeutics and diagnostics
(2026-04-13)The P2Y<sub>12</sub> receptor (P2Y<sub>12</sub>R), a G protein-coupled receptor activated by adenosine diphosphate (ADP), has traditionally been associated with platelet aggregation and targeted for antithrombotic therapy. ...
