Fate-Mapping of Yolk Sac-Derived Macrophages
Fate-Mapping of Yolk Sac-Derived Macrophages
dc.contributor.author | Splichalova, Iva | |
dc.contributor.author | Mass, Elvira | |
dc.contributor.editor | Mass, Elvira | |
dc.date.accessioned | 2023-09-27T13:19:34Z | |
dc.date.available | 2023-09-27T13:19:34Z | |
dc.date.issued | 29.08.2023 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11811/11072 | |
dc.description.abstract | To better understand the distinct functions of yolk-sac-derived tissue-resident macrophages (TRMs) and bone-marrow-derived macrophages in homeostasis and disease, it is important to trace the ontogeny of these cells. The majority of TRMs originate from erythro-myeloid progenitors (EMPs). EMPs develop into pre-macrophages (pMacs), which can be detected starting at embryonic developmental day (E)9.0, and which give rise to all TRM during early development. pMacs start expressing the gene Cx3cr1, allowing us to genetically target the early yolk-sac wave of pMacs and their progeny. Here, we describe the protocol for the identification of yolk sac-derived TRMs utilizing in utero labelling of the inducible fate mapping Cx3cr1CreERT; Rosa26LSL-eYFP mouse model. | en |
dc.format.extent | 9 | |
dc.language.iso | eng | |
dc.relation.ispartofseries | Methods in Molecular Biology ; 2713 | |
dc.rights | Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | macrophages | |
dc.subject | fate-mapping | |
dc.subject.ddc | 570 Biowissenschaften, Biologie | |
dc.title | Fate-Mapping of Yolk Sac-Derived Macrophages | |
dc.type | Teil eines Buches oder einer Monografie | |
dc.publisher.name | Springer | |
dc.publisher.location | New York | |
dc.rights.accessRights | openAccess | |
dcterms.bibliographicCitation.pagestart | 129 | |
dcterms.bibliographicCitation.pageend | 137 | |
dc.relation.doi | https://doi.org/10.1007/978-1-0716-3437-0_8 | |
dcterms.bibliographicCitation.booktitle | Tissue-Resident Macrophages: Methods and Protocols | |
ulbbn.pubtype | Zweitveröffentlichung |
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