Cytokine Production of CD56bright Natural Killer Cells From Human Immunodeficiency Virus–Infected Individuals Under Effective Antiretroviral Therapy
Cytokine Production of CD56bright Natural Killer Cells From Human Immunodeficiency Virus–Infected Individuals Under Effective Antiretroviral Therapy
Dokument öffnen (478.6KB)Datum der Veröffentlichung
01.09.2022Verlag / herausgebende Einrichtung
Oxford Univ. PressVerlagsort
OxfordMetadaten
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Zitierbarer Link (Handle URI) 
https://hdl.handle.net/20.500.11811/11487
Inhalt
Human immunodeficiency virus (HIV) infection is associated with impaired natural killer (NK) cell activity, which is only incompletely restored under antiretroviral therapy. Analyzing the bioenergetics profiles of oxygen consumption, we observed that several parameters were significantly reduced in HIV+ NK cells, indicating a mitochondrial defect. Accordingly, we found HIV+ CD56bright NK cells to display a decreased mitochondrial membrane potential and mitochondrial mass. Both parameters were positively correlated with interferon gamma (IFN-γ) production of NK cells. Finally, we demonstrated that stimulation of HIV+ NK cells with MitoTEMPO, a mitochondria-targeting antioxidant, significantly improved IFN-γ production. We identified mitochondrial dysfunction as a mechanism that contributes to impaired NK cell function.
Schlagwörter
HIV, mitochondrial dysfunction, NK cell, IFN-gamma, immunometabolism
Klassifikation (DDC)
610 Medizin, Gesundheit 570 Biowissenschaften, BiologieErschienen in
The journal of infectious diseases, 2022, vol. 226, iss. 5, S. 901-906Erstpublikation
https://doi.org/10.1093/infdis/jiac103ToVinh, Michael; Hörr, Gregor; Dobrikova, Kristiyana; Gotter, Christina; Rommel, Clemens; Hoffmeister, Christoph; Raabe, Jan; Kaiser, Kim M.; Finnemann, Claudia; Bischoff, Jenny; Rieke, Gereon J.; Wilhelm, Christoph; Schmitt, Vanessa; Möhl, Christoph; Aghabeig, Mansoureh; Schwarze-Zander, Carolynne; Boesecke, Christoph; van Bremen, Kathrin; Wasmuth, Jan-Christian; Strassburg, Christian P.; Rockstroh, Jürgen K.; Spengler, Ulrich; Krämer, Benjamin; Nattermann, Jacob: Cytokine Production of CD56bright Natural Killer Cells From Human Immunodeficiency Virus–Infected Individuals Under Effective Antiretroviral Therapy. In: The journal of infectious diseases. 2022, vol. 226, iss. 5, 901-906.
Online-Ausgabe in bonndoc: https://hdl.handle.net/20.500.11811/11487
Online-Ausgabe in bonndoc: https://hdl.handle.net/20.500.11811/11487
@article{handle:20.500.11811/11487,
author = {{Michael ToVinh} and {Gregor Hörr} and {Kristiyana Dobrikova} and {Christina Gotter} and {Clemens Rommel} and {Christoph Hoffmeister} and {Jan Raabe} and {Kim M. Kaiser} and {Claudia Finnemann} and {Jenny Bischoff} and {Gereon J. Rieke} and {Christoph Wilhelm} and {Vanessa Schmitt} and {Christoph Möhl} and {Mansoureh Aghabeig} and {Carolynne Schwarze-Zander} and {Christoph Boesecke} and {Kathrin van Bremen} and {Jan-Christian Wasmuth} and {Christian P. Strassburg} and {Jürgen K. Rockstroh} and {Ulrich Spengler} and {Benjamin Krämer} and {Jacob Nattermann}},
title = {Cytokine Production of CD56bright Natural Killer Cells From Human Immunodeficiency Virus–Infected Individuals Under Effective Antiretroviral Therapy},
publisher = {Oxford Univ. Press},
year = 2022,
month = sep,
journal = {The journal of infectious diseases},
volume = 2022, vol. 226,
number = iss. 5,
pages = 901--906,
note = {Human immunodeficiency virus (HIV) infection is associated with impaired natural killer (NK) cell activity, which is only incompletely restored under antiretroviral therapy. Analyzing the bioenergetics profiles of oxygen consumption, we observed that several parameters were significantly reduced in HIV+ NK cells, indicating a mitochondrial defect. Accordingly, we found HIV+ CD56bright NK cells to display a decreased mitochondrial membrane potential and mitochondrial mass. Both parameters were positively correlated with interferon gamma (IFN-γ) production of NK cells. Finally, we demonstrated that stimulation of HIV+ NK cells with MitoTEMPO, a mitochondria-targeting antioxidant, significantly improved IFN-γ production. We identified mitochondrial dysfunction as a mechanism that contributes to impaired NK cell function.},
url = {https://hdl.handle.net/20.500.11811/11487}
}
author = {{Michael ToVinh} and {Gregor Hörr} and {Kristiyana Dobrikova} and {Christina Gotter} and {Clemens Rommel} and {Christoph Hoffmeister} and {Jan Raabe} and {Kim M. Kaiser} and {Claudia Finnemann} and {Jenny Bischoff} and {Gereon J. Rieke} and {Christoph Wilhelm} and {Vanessa Schmitt} and {Christoph Möhl} and {Mansoureh Aghabeig} and {Carolynne Schwarze-Zander} and {Christoph Boesecke} and {Kathrin van Bremen} and {Jan-Christian Wasmuth} and {Christian P. Strassburg} and {Jürgen K. Rockstroh} and {Ulrich Spengler} and {Benjamin Krämer} and {Jacob Nattermann}},
title = {Cytokine Production of CD56bright Natural Killer Cells From Human Immunodeficiency Virus–Infected Individuals Under Effective Antiretroviral Therapy},
publisher = {Oxford Univ. Press},
year = 2022,
month = sep,
journal = {The journal of infectious diseases},
volume = 2022, vol. 226,
number = iss. 5,
pages = 901--906,
note = {Human immunodeficiency virus (HIV) infection is associated with impaired natural killer (NK) cell activity, which is only incompletely restored under antiretroviral therapy. Analyzing the bioenergetics profiles of oxygen consumption, we observed that several parameters were significantly reduced in HIV+ NK cells, indicating a mitochondrial defect. Accordingly, we found HIV+ CD56bright NK cells to display a decreased mitochondrial membrane potential and mitochondrial mass. Both parameters were positively correlated with interferon gamma (IFN-γ) production of NK cells. Finally, we demonstrated that stimulation of HIV+ NK cells with MitoTEMPO, a mitochondria-targeting antioxidant, significantly improved IFN-γ production. We identified mitochondrial dysfunction as a mechanism that contributes to impaired NK cell function.},
url = {https://hdl.handle.net/20.500.11811/11487}
}
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