Publikationen: Auflistung Publikationen nach Erscheinungsdatum
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UDP-glucuronosyltransferase polymorphisms affect diethylnitrosamine-induced carcinogenesis in humanized transgenic mice
Landerer, Steffen; Kalthoff, Sandra; Paulusch, Stefan; Strassburg, Christian P. (2020-08-28)UDP-glucuronosyltransferase (UGT) 1A enzymes detoxify a broad array of exogenous compounds including environmental toxins and carcinogens. Case-control studies identified genetic variations in UGT1A genes leading to reduced ... -
Cytokine Production of CD56bright Natural Killer Cells From Human Immunodeficiency Virus–Infected Individuals Under Effective Antiretroviral Therapy
ToVinh, Michael; Hörr, Gregor; Dobrikova, Kristiyana; Gotter, Christina; Rommel, Clemens; Hoffmeister, Christoph; Raabe, Jan; Kaiser, Kim M.; Finnemann, Claudia; Bischoff, Jenny; Rieke, Gereon J.; Wilhelm, Christoph; Schmitt, Vanessa; Möhl, Christoph; Aghabeig, Mansoureh; Schwarze-Zander, Carolynne; Boesecke, Christoph; van Bremen, Kathrin; Wasmuth, Jan-Christian; Strassburg, Christian P.; Rockstroh, Jürgen K.; Spengler, Ulrich; Krämer, Benjamin; Nattermann, Jacob (2022-09-01)Human immunodeficiency virus (HIV) infection is associated with impaired natural killer (NK) cell activity, which is only incompletely restored under antiretroviral therapy. Analyzing the bioenergetics profiles of oxygen ... -
Second-line and third-line therapy with nanoliposomal irinotecan (nal-IRI) in pancreatic cancer: a single-center experience and review of literature
Möhring, Christian; Frontado Graffe, Freddy José; Bartels, Alexandra; Sadeghlar, Farsaneh; Zhou, Taotao; Mahn, Robert; Marinova, Milka; Feldmann, Georg; Brossart, Peter; Glowka, Tim; Kalff, Jörg; Strassburg, Christian; Gonzalez-Carmona, Maria (2023-02-15)Background: Prognosis of patients with pancreatic cancer is still extremely poor. First-line palliative therapies with FOLFIRINOX or gemcitabine/nab-paclitaxel have been established in the last decade. In the second-line, ... -
Deficient immune response following SARS-CoV-2 vaccincation in patients with hepatobiliary carcinoma: A forgotten, vulnerable group of patients
Monin, Malte; Baier, Leona; Gorny, Jens; Berger, Moritz; Zhou, Taotao; Mahn, Robert; Sadeghlar, Farsaneh; Möhring, Christian; Boesecke, Christoph; van Bremen, Kathrin; Rockstroh, Jürgen; Strassburg, Christian; Eis-Hübinger, Anna-Maria; Schmid, Matthias; Gonzalez-Carmona, Maria (2023-05-10)<strong>Introduction:</strong> Data on immune response rates following vaccination for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in patients with hepatobiliary carcinoma (HBC) are rare. However, impaired ... -
Comparison between regular additional endobiliary radiofrequency ablation and photodynamic therapy in patients with advanced extrahepatic cholangiocarcinoma under systemic chemotherapy
Möhring, Christian; Khan, Oliver; Zhou, Taotao; Sadeghlar, Farsaneh; Mahn, Robert; Kaczmarek, Dominik J.; Dold, Leona; Toma, Marieta; Marinova, Milka; Glowka, Tim; Matthaei, Hanno; Manekeller, Steffen; Kalff, Jörg C.; Strassburg, Christian; Weismüller, Tobias J.; Gonzalez-Carmona, Maria A. (2023-08-29)<strong>Background and aims: </strong>Extrahepatic cholangiocarcinoma (eCCA) remains a malignancy with a dismal prognosis. The first-line standard of care includes systemic chemotherapy (SC) and biliary drainage through ... -
Regulatory T Cell Inhibition by P60 Combined with Adenoviral AFP Transduced Dendritic Cells for Immunotherapy of Hepatocellular Carcinoma
Sadeghlar, Farsaneh; Seelemann, Julia; Vogt, Annabelle; Möhring, Christian; Zhou, Taotao; Mahn, Robert; Kornek, Miroslaw; Lukacs-Kornek, Veronika; Casares, Noelia; Lasarte, Juan José; Sarobe, Pablo; Beekum, Cornelius van; Matthaei, Hanno; Manekeller, Steffen; Kalff, Jörg; Schmidt-Wolf, Ingo G.H.; Strassburg, Christian P.; Gonzalez-Carmona, Maria A. (2023-10-17)<strong>Background & Aims:</strong> Vaccination with tumor-associated antigen-pulsed dendritic cells leads to specific T-cell response against hepato-cellular carcinoma. However, clinical response has been shown to be ... -
Longitudinal Study of SARS-CoV-2 Vaccinations and Infections in Patients with Gastrointestinal Cancer: Stabilizing Immune Responses and Neutralizing Emerging Variants with Variant-Adapted Antigen Exposures
Gonzalez-Carmona, Maria A.; Schmitz, Alina M.; Berger, Moritz; Baier, Leona I.; Gorny, Jens G.; Sadeghlar, Farsaneh; Anhalt, Thomas; Zhou, Xin; Zhou, Taotao; Mahn, Robert; Möhring, Christian; Linnemann, Thomas; Schmid, Matthias; Strassburg, Christian P.; Boesecke, Christoph; Rockstroh, Jürgen K.; Eis-Hübinger, Anna-Maria; Monin, Malte B. (2024-12-19)This longitudinal study examined how active gastrointestinal (GI) cancer types affect immune responses to SARS-CoV-2, focusing on the ability to neutralize the Omicron variants. Patients with GI cancer (<em>n</em> = 168) ...