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Einfluss der Cyclin-abhängigen Kinase 5 auf die Expression des Programmed Cell Death Ligand 1 in murinen Pankreaskarzinomen im Vergleich verschiedener Analysemethoden
(2023-03-23)
Einleitung: Programmed Cell Death Ligand 1 (PD-L1) ist ein immuninhibitorisches Molekül, das für gewöhnlich von bestimmten Immunzellen oder dendritischen Zellen exprimiert wird. Auch verschiedene Tumoren ...
Validation, determinants and impact of medication use
(2024-04-02)
In recent decades, global medication consumption has increased substantially due to an aging population and more emphasis on preventative treatment. As medication use increases, concerns naturally arise regarding the ...
Obesity impairs virus-specific memory CD8+ T cell signalling and function
(2024-04-11)
The main function of the immune system is to protect the host against invading pathogens. Immunological memory is formed after a primary infection and serves to provide protection in a fast and vigorous manner upon secondary ...
Pilzkontaminationen in Korneatransplantaten: Effektivität antimykotischer Medienzusätze und Anwendbarkeit molekularbiologischer Detektionsmethoden
(2023-10-16)
Postoperative Infektionen stellen eine schwerwiegende Komplikationen nach Korneatransplantation dar. In den letzten Jahren wurde ein Anstieg der Inzidenz von Pilzinfektionen nach Keratoplastik festgestellt. Aktuell werden ...
Impact of aging and enriched environment on α-synuclein propagation
(2022-04-06)
Parkinson's disease (PD) is the second most common neurodegenerative disease. The prevalence of sporadic PD results from a complex interaction of demographic, genetic, and environmental factors. Age is one of the strongest ...
Protein markers of inflammation and ageing in a European multi-centre dementia cohort
(2024-03-01)
Inflammation plays a key role in Alzheimerʼs disease (AD) progression. Microglia in the AD brain are exposed to pathological amyloid β (Aβ42) and tau peptide aggregates, resulting in the NLRP3 inflammasome activation ...
Organization principles of thalamocortical input onto deep-layer inhibitory neurons of the barrel cortex
(2024-02-28)
Thalamus functions as the main route by which incoming sensory information reaches the cerebral cortex. Thalamic nuclei will receive input from the sensory receptors in the periphery and relay it to different areas in the ...
Role of TLR2 in immune sensing of gut microbiota in RNA virus induced glomerulonephritis
(2024-05-22)
Chronically infected patients with human immune deficiency virus (HIV) are at high risk of developing autoimmune diseases. Despite successful anti-retroviral therapy, autoimmune diseases and renal diseases affect 10–15 % ...