E-Dissertationen: Suche
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Investigation of SECISBP2 mutations and potential viral SECIS element recruitment
(2021-07-15)
The 21st amino acid selenocysteine (Sec) is encoded by the UGA codon. In order to recode the canonical stop codon additional factors are needed in mammals including the selenocysteine-insertion-sequence (SECIS) ......
Untersuchungen mit dem Ecdyson-induzierbaren Promotorsystem an humanen Tumorzelllinien
(2007)
Induzierbare Genexpressionssysteme ermöglichen die Untersuchung von Genfunktionen in Zellen, besonders der dortigen Wirkung toxischer und teratogener Proteine, sowie der regulierten Expression von antisense Sequenzen oder ...
Vergleichende Expressionsanalyse von Tetraspanin-5 im sich entwickelnden Kleinhirn der Maus und im Medulloblastomgewebe von Mensch und Maus
(2007)
Tetraspanin-5 gehört zur Familie der Tetraspanine, einer Familie von 4-Transmembranproteinen, die sich durch ihre typische Tertiärstruktur auszeichnen. Diese befähigt die Tetraspanine dazu, sowohl mit der extrazellulären ...
Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations: The establishment of translating ribosome affinity purification
(2020-11-04)
Recoding of in-frame UGA/Seccodon in selenoproteins requires a complex translational machinery. The core of this event is the interaction between selenocysteine insertion sequence (SECIS element) in the 3’UTR of ...
Structural and functional principles of long-range connectivity in the rat vibrissal system
(2020-11-05)
Pyramidal tract neurons (PTs) represent the major output cell type of the mammalian neocortex. Integrating feedforward thalamo-cortical (TC) and recurrent intracortical (IC) inputs with those from top down cortical-cortical ...
Search for exosomes in NG2-glial cells
(2022-02-17)
NG2-glial cells is an abundant and widely distributed subtype of glia, featuring properties not typically associated with mature glial cells, such as the ability to receive synaptic input from neurons, or adult proliferation. ...
Impact of chronic liver inflammation on adaptive immune responses to viral infection
(2020-03-11)
A common complication in patients suffering from chronic liver inflammation and fibrosis is the enhanced susceptibility to viral infections and weak responses to vaccination, which are associated with significant co-morbidities. ...
Immune defense mechanisms against Legionella longbeachae
(2020-01-30)
The pulmonary epithelial barrier is the first line of defense against pathogens invading the lungs. If those are able to overcome this first barrier, myeloid cells of the innate immune system are instrumental for the ......
Participation of Ste20-like kinase-deficient neurons in the abnormal circuitry of focal epileptogenic lesions
(2022-01-03)
Focal epileptogenic lesions displaying morphologically altered neurons are frequently associated with devastating and therapy-refractory epilepsies. However, it is still unsolved how dysplastic neurons contribute to the ...
Investigating the ability of RIG-I agonists to provide protection in mouse and ferret models of respiratory virus infection
(2022-05-17)
Respiratory infections caused by influenza A virus (IAV) or respiratory syncytial virus (RSV) lead to substantial morbidity and mortality. Treatment options are limited and there is urgent need for the development of ......
