E-Dissertationen: Suche
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T cell response to an MHC-II restricted epitope of rodent malaria
(2022-02-01)
Malaria is caused by different Plasmodium species that can infect a variety of animals including humans and rodents. The life cycle of these parasites is complex and includes a liver stage followed by a blood-stage in their ......
Investigation of SECISBP2 mutations and potential viral SECIS element recruitment
(2021-07-15)
The 21st amino acid selenocysteine (Sec) is encoded by the UGA codon. In order to recode the canonical stop codon additional factors are needed in mammals including the selenocysteine-insertion-sequence (SECIS) ......
Structure and function study of HCN1 channel by forming a lattice on the membrane
(2020-09-08)
Hyperpolarized-activated cyclic nucleotide-gated (HCN) channels play complex and diverse roles in the regulation of neuronal and network excitability. Aberrant expression, trafficking, and post-translational modifications ...
Understanding telomere dynamics with G-quadruplex secondary structures in S. cerevisiae
(2022-03-10)
Telomeres are specialized nucleoprotein structures at the end of linear eukaryotic chromosomes, vital for safeguarding of genetic material. They inhibit nucleolytic degradation, end to end fusion and unwanted recombination. ......
Astrocyte morphology determines properties of the astroglial networks
(2021-09-29)
Astrocytes are very abundant glial cells in the brain. They perform many functions: provision of nutrient to the neurons, maintenance of extracellular ion balance, shaping of network operations and synaptic signaling and ...
Aktivierung des angeborenen Immunsystems im Zentralnervensystem nach subchronischer Alkoholbehandlung im Mausmodell
(2020-06-03)
Alkohol ist als kulturell anerkanntes Rauschmittel in seinen ökonomischen, sozialen und gesundheitlichen Risiken weiterhin unterschätzt. In der Literatur zeigen sich Hinweise auf die Relevanz unterschiedlicher Trinkmuster ...
Bilateral inflammation after unilateral UVR-B irradiation: Ocular cross-talk and immunomodulation between exposed and unexposed, contralateral eye
(2021-01-29)
The presented study investigates the influence of exposure of one eye to UVR-B on the unexposed, partner eye in vivo in a mouse model. Furthermore, we try to answer the question whether this sympathizing reaction of the ...
The role of sympathetic neurons in modulating resident muscularis macrophage functions during postoperative ileus and mucosal antimicrobial responses in homeostasis: Sympathetic neurons in intestinal homeostasis and disease
(2022-02-09)
Introduction: The sympathetic nervous system (SNS) innervates large parts of the gastrointestinal tract. Its projections are densely found in tunica muscularis externa and reach up to the mucosa, the ...
Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations: The establishment of translating ribosome affinity purification
(2020-11-04)
Recoding of in-frame UGA/Seccodon in selenoproteins requires a complex translational machinery. The core of this event is the interaction between selenocysteine insertion sequence (SECIS element) in the 3’UTR of ...
Structural and functional principles of long-range connectivity in the rat vibrissal system
(2020-11-05)
Pyramidal tract neurons (PTs) represent the major output cell type of the mammalian neocortex. Integrating feedforward thalamo-cortical (TC) and recurrent intracortical (IC) inputs with those from top down cortical-cortical ...