E-Dissertationen: Search
Now showing items 1-5 of 5
RIG-I agonists as effective anti-viral prophylaxis and treatment in a mouse model of severe SARS-CoV-2 infection
(2022-07-08)
The recent outbreak of the COVID-19 pandemic highlights the need for novel prophylactic and therapeutic countermeasures against newly emerging viruses. Innate immune receptor agonists are considered to be a promising new ...
Functions of the DEAH-box helicase DHX36 in type I interferon signaling
(2023-01-06)
The induction of type I interferons (IFN) is a hallmark of foreign nucleic acids immune sensing by the innate immune system. Based on the universal molecular structure of DNA and RNA throughout all kingdoms of life, the ...
Investigating the ability of RIG-I agonists to provide protection in mouse and ferret models of respiratory virus infection
(2022-05-17)
Respiratory infections caused by influenza A virus (IAV) or respiratory syncytial virus (RSV) lead to substantial morbidity and mortality. Treatment options are limited and there is urgent need for the development of ......
Interplay of IKKs and IKK-related kinases in antiviral nucleic acid receptor signaling in human monocytes
(2022-06-21)
Monocytes and monocyte-derived cells are equipped with pattern recognition receptors (PRRs) that detect conserved components of pathogens and in response initiate signaling cascades that result in the production of warning ...
Influence of antiviral RNA binding effector proteins on innate immune responses
(2024-08-06)
The efficient elimination of viruses is initiated by the recognition of the viral nucleic acid genome or replication intermediates through innate immune receptors. Several different receptors specifically detect double ......