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Investigation of SECISBP2 mutations and potential viral SECIS element recruitment
(2021-07-15)
The 21st amino acid selenocysteine (Sec) is encoded by the UGA codon. In order to recode the canonical stop codon additional factors are needed in mammals including the selenocysteine-insertion-sequence (SECIS) ......
Untersuchungen mit dem Ecdyson-induzierbaren Promotorsystem an humanen Tumorzelllinien
(2007)
Induzierbare Genexpressionssysteme ermöglichen die Untersuchung von Genfunktionen in Zellen, besonders der dortigen Wirkung toxischer und teratogener Proteine, sowie der regulierten Expression von antisense Sequenzen oder ...
Vergleichende Expressionsanalyse von Tetraspanin-5 im sich entwickelnden Kleinhirn der Maus und im Medulloblastomgewebe von Mensch und Maus
(2007)
Tetraspanin-5 gehört zur Familie der Tetraspanine, einer Familie von 4-Transmembranproteinen, die sich durch ihre typische Tertiärstruktur auszeichnen. Diese befähigt die Tetraspanine dazu, sowohl mit der extrazellulären ...
Synaptische Innervation als Richtungsgeber für migrierende Vorläufer zentralnervöser Interneurone
(2016-11-30)
Interneuron-Vorläuferzellen migrieren während der Entwicklung weite Strecken von den Orten, an denen sie generiert werden, zu ihren Bestimmungsorten, an denen sie sich differenzieren und synaptisch in neuronale Netzwerke ...
Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations: The establishment of translating ribosome affinity purification
(2020-11-04)
Recoding of in-frame UGA/Seccodon in selenoproteins requires a complex translational machinery. The core of this event is the interaction between selenocysteine insertion sequence (SECIS element) in the 3’UTR of ...
Structural and functional principles of long-range connectivity in the rat vibrissal system
(2020-11-05)
Pyramidal tract neurons (PTs) represent the major output cell type of the mammalian neocortex. Integrating feedforward thalamo-cortical (TC) and recurrent intracortical (IC) inputs with those from top down cortical-cortical ...
Search for exosomes in NG2-glial cells
(2022-02-17)
NG2-glial cells is an abundant and widely distributed subtype of glia, featuring properties not typically associated with mature glial cells, such as the ability to receive synaptic input from neurons, or adult proliferation. ...
Impact of chronic liver inflammation on adaptive immune responses to viral infection
(2020-03-11)
A common complication in patients suffering from chronic liver inflammation and fibrosis is the enhanced susceptibility to viral infections and weak responses to vaccination, which are associated with significant co-morbidities. ...
Immune defense mechanisms against Legionella longbeachae
(2020-01-30)
The pulmonary epithelial barrier is the first line of defense against pathogens invading the lungs. If those are able to overcome this first barrier, myeloid cells of the innate immune system are instrumental for the ......
The role of innate lymphoid cells in liver disease: Identification of a hepatic IL-13-producing ILC3-like population potentially involved in liver fibrosis
(2022-05-23)
Innate lymphoid cells (ILCs) are a family of innate immune cells that mirror the functionality of T lymphocytes but do not express rearranged antigen receptors. As tissue-resident cells, ILCs primarily reside in peripheral ...