E-Dissertationen: Search
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Activation of the innate immune system by endoplasmic reticulum stress and proteasome inhibition
(2023-08-24)
The impact of proteotoxic stress on innate immune activation is currently unclear. Here, I investigated differential effects of ER stress and proteasome inhibition using genetically modified cell lines and primary human ...
Inflammation-dependent differentiation of two distinct regulatory T cell populations in the visceral adipose tissue shapes systemic metabolism
(2023-12-07)
Visceral adipose tissue (VAT) is an endocrine organ critical for energy storage and metabolic homeostasis. It harbours a plethora of immune cells, which play an important role in maintaining tissue homeostasis. A large ...
Contribution of SIGLEC-11 and SIGLEC-16 receptors to neuro-inflammation and neurodegeneration
(2023-02-14)
Brain aging is a multifactorial process including accumulation of aged lipids and proteins,
neuroinflammation and loss of neurons. SIGLEC-11 and SIGLEC-16 are paired opposite inhibitory- versus activatory-signaling ...
Determining the epigenetic synergy of a repurposed drug and identification of prognosis-related lncRNAs in liver cancer and hematologic malignancies
(2023-11-02)
Background: Epigenetics is crucial in cancer research, revealing its impact on diverse cancer types' development and progression. Epigenetic-targeting drugs show promise in improving patient outcomes, but ...
Einfluss der Cyclin-abhängigen Kinase 5 auf die Expression des Programmed Cell Death Ligand 1 in murinen Pankreaskarzinomen im Vergleich verschiedener Analysemethoden
(2023-03-23)
Einleitung: Programmed Cell Death Ligand 1 (PD-L1) ist ein immuninhibitorisches Molekül, das für gewöhnlich von bestimmten Immunzellen oder dendritischen Zellen exprimiert wird. Auch verschiedene Tumoren ...