E-Dissertationen: Search
Now showing items 1-10 of 23
Investigation of SECISBP2 mutations and potential viral SECIS element recruitment
(2021-07-15)
The 21st amino acid selenocysteine (Sec) is encoded by the UGA codon. In order to recode the canonical stop codon additional factors are needed in mammals including the selenocysteine-insertion-sequence (SECIS) ......
Structure and function study of HCN1 channel by forming a lattice on the membrane
(2020-09-08)
Hyperpolarized-activated cyclic nucleotide-gated (HCN) channels play complex and diverse roles in the regulation of neuronal and network excitability. Aberrant expression, trafficking, and post-translational modifications ...
Astrocyte morphology determines properties of the astroglial networks
(2021-09-29)
Astrocytes are very abundant glial cells in the brain. They perform many functions: provision of nutrient to the neurons, maintenance of extracellular ion balance, shaping of network operations and synaptic signaling and ...
Aktivierung des angeborenen Immunsystems im Zentralnervensystem nach subchronischer Alkoholbehandlung im Mausmodell
(2020-06-03)
Alkohol ist als kulturell anerkanntes Rauschmittel in seinen ökonomischen, sozialen und gesundheitlichen Risiken weiterhin unterschätzt. In der Literatur zeigen sich Hinweise auf die Relevanz unterschiedlicher Trinkmuster ...
Bilateral inflammation after unilateral UVR-B irradiation: Ocular cross-talk and immunomodulation between exposed and unexposed, contralateral eye
(2021-01-29)
The presented study investigates the influence of exposure of one eye to UVR-B on the unexposed, partner eye in vivo in a mouse model. Furthermore, we try to answer the question whether this sympathizing reaction of the ...
Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations: The establishment of translating ribosome affinity purification
(2020-11-04)
Recoding of in-frame UGA/Seccodon in selenoproteins requires a complex translational machinery. The core of this event is the interaction between selenocysteine insertion sequence (SECIS element) in the 3’UTR of ...
Structural and functional principles of long-range connectivity in the rat vibrissal system
(2020-11-05)
Pyramidal tract neurons (PTs) represent the major output cell type of the mammalian neocortex. Integrating feedforward thalamo-cortical (TC) and recurrent intracortical (IC) inputs with those from top down cortical-cortical ...
Establishment of an inducible human pluripotent stem cell-based 3D model of Alzheimer's disease
(2020-11-16)
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease in the aged population. The vast majority of cases are sporadic, however, various mutations may cause early-onset, familial AD (FAD) variants. AD is ...
Low molecular weight polysialic acid prevents lipopolysaccharide-induced inflammatory dopaminergic neurodegeneration in humanized SIGLEC11 transgenic mice
(2021-07-13)
Parkinson’s disease is one of the most common neurodegenerative diseases in the elderly population, with a pathophysiology linked to neuroinflammation, complement activation and oxidative damage. Soluble polysialic acid ...
Characterisation of Extracellular Vesicles Released upon NLRP3 Activation and Their Impact on Bystander Cells
(2020-02-17)
Inflammasomes are cytosolic multi-protein complexes that assemble upon detection of danger signals of infectious or sterile origin. Activation of the NOD-like receptor NLRP3 results in activation of caspase-1, which ...