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Lipid droplet formation drives pathogenic ILC2 responses in airway inflammation
(2020-06-08)
The Western world is affected by a dramatic increase of chronic inflammatory diseases like asthma, Crohn’s disease and psoriasis. Innate lymphoid cells (ILC) play an important role in the control and maintenance of barrier ...
Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations: The establishment of translating ribosome affinity purification
(2020-11-04)
Recoding of in-frame UGA/Seccodon in selenoproteins requires a complex translational machinery. The core of this event is the interaction between selenocysteine insertion sequence (SECIS element) in the 3’UTR of ...
