E-Dissertationen: Suche
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Somatic cell-derived extracellular vesicles and phenotypic outcomes in the next generation
(2023-05-31)
Evidence from both human and animal studies demonstrate that paternal experiences and exposures can cause phenotypic changes in the next generation. Extracellular vesicles (EVs) released by somatic cells are hypothesised ...
Extracellular Vesicles in Hepatobiliary Cancer Management
(2023-04-19)
Cancer is a global health problem that will intensify in the upcoming years and decades. Hepatobiliary cancers, comprising hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA) and gallbladder carcinoma (GbCA), are among ...
Functions of the DEAH-box helicase DHX36 in type I interferon signaling
(2023-01-06)
The induction of type I interferons (IFN) is a hallmark of foreign nucleic acids immune sensing by the innate immune system. Based on the universal molecular structure of DNA and RNA throughout all kingdoms of life, the ...
PML and its degradation by arsenic trioxide in interferon-mediated neuro-inflammation
(2023-02-06)
Activation of interferon type-I (IFN-I) production and downstream signaling pathways mediate the tissue response to pathogens such as viruses, but its aberrant activation has been suggested to contribute to the aging process ...
Pharmacologic intervention in macrophage metabolism: Mitochondrial pyruvate carrier inhibition by Mitoglitazone modulates inflammation
(2023-08-09)
Upon Toll-like receptor (TLR) activation, macrophages rapidly change their transcriptional- and translational network and rewire their metabolism. Mitochondrial pyruvate import via the mitochondrial pyruvate carrier (MPC) ...
Legionnaires' Disease - the impact of cigarette smoke and functional lung recovery
(2023-02-14)
Legionnaires’ Disease is a severe type of pneumonia most commonly caused by the bacterial species Legionella pneumophila and Legionella longbeachae. Epidemiological studies show that cigarette smoke is a major risk factor ......
Characterization of the zinc-sensitive metal-regulatory transcription factor 1 in hippocampal epileptic network formation using an animal model of Temporal Lobe Epilepsy
(2023-10-02)
Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy. It usually occurs after a transient brain insult, including status epilepticus (SE), which triggers a latent period of epileptogenesis prior to the ......
A basal forebrain to midbrain circuit drives exploratory locomotion
(2023-10-26)
Locomotion is a fundamental behavior that comprises different specialized neuronal networks. In the basal forebrain, the glutamatergic neurons of the medial septum and diagonal band of Broca (MSDBglu) can initiate ......
Role of the chemokines CCL17 and CCL22 in bacterial infection and IL-33-induced immune responses
(2023-11-24)
The chemokines CCL17 and CCL22 are primarily expressed by dendritic cells (DC) and macrophages. Both chemokines share the receptor CCR4, which is expressed on DC and macrophages as well as on a variety of different T cell ......
RIM4 deficiency leads to reduced somato-dendritic excitability of cerebellar Purkinje cells
(2023-12-14)
Synaptic function is determined by the release machinery at the active zone which is composed of a large number of synaptic proteins including RIMs. The large RIMs are key components of the presynaptic active zone that ...