Spinneker, Andre: Serum lipid status in European adolescents : associations with age, gender, maturity, body mass index, percentage body fat, and fat free mass. - Bonn, 2010. - Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn.
Online-Ausgabe in bonndoc: https://nbn-resolving.org/urn:nbn:de:hbz:5N-21418
@phdthesis{handle:20.500.11811/4201,
urn: https://nbn-resolving.org/urn:nbn:de:hbz:5N-21418,
author = {{Andre Spinneker}},
title = {Serum lipid status in European adolescents : associations with age, gender, maturity, body mass index, percentage body fat, and fat free mass},
school = {Rheinische Friedrich-Wilhelms-Universität Bonn},
year = 2010,
month = jun,

note = {The development of cardiovascular diseases and atherosclerosis and its relation to lipids (e.g. cholesterol, lipoproteins, and fatty acids [FA]) is well established and begins in childhood and adolescence. Beside that, an adequate lipid profile is also important for normal growth and development in youth. However, less is known about how factors associated with adolescence like age, gender, maturity, body mass index (BMI), body fat (BF), and fat free mass (FFM) are influencing lipid profiles in healthy European adolescents.
Consequently, this thesis investigated the association of age, gender, maturity, BMI, BF, and FFM with the lipid profile of European adolescents within the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) Study. More precisely, the investigated associations of the factors mentioned above with clinical lipid parameters (i.e. total cholesterol (TC), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL), triglycerides (TG), lipoprotein(a) [Lp(a)], and the apolipoproteins (apo) A-1 and B) as well as with several lipid and lipoprotein ratios are described in chapter 4. The relation of age, gender, maturity, BMI, BF, and FFM to the FA profile is presented in chapter 5. The results of the association of age, gender, maturity, BMI, BF, and FFM with several FA ratios are provided in chapter 6. Further, in chapter 7 the relationships between selected FA and TC, HDL, LDL, TG, Lp(a), apo A-1 and B are summarized.
Generally, the results were as follows: the clinical lipid parameters were higher in girls than in boys. Furthermore, almost all absolute FA values were higher in girls than in boys whereas the relative FA profile showed less clear gender differences.
Triglyceride levels were positively associated with age in boys. Further, in both boys and girls some FA of the absolute FA profile and the relative FA profile were related to age.
Progression in maturity was associated with lower TC and HDL levels in boys and changes in TC, LDL, and apo B levels without clear direction in girls. Additionally, maturity was associated with fluctuations in the FA profile without clear pattern in boys and girls.
Body mass index was hardly associated with the lipid profile of boys. By contrast, TG levels and several lipid and lipoprotein ratios increased and HDL levels decreased with higher BMI status in girls.
Body fat was mainly associated with changes in the male subjects. In boys, TG, LDL, and several lipid and lipoprotein ratios increased, whereas HDL decreased with higher body fat. The FA profile and FA ratios showed minimal associations with body fat.
Fat free mass was positively associated with C20:5ω3c/C18:3ω3c ratios in boys and also associated with some FA in both sexes.
In chapter 7, individual serum FA (i.e. C16:0, C18:0, C18:1ω9c, C18:2ω6c, C18:3ω3c, C20:4ω6c, C20:5ω3c, and C22:6ω3c) were associated with clinical lipid parameters (i.e. TC, HDL, LDL, TG, Lp(a), apo A-1, and apo B) using multiple linear regression models. The effect of individual FA on several lipids and lipoproteins was minimal. The highest association was found between C16:0 and C18:0 with TG levels. In boys and girls, approximately 7% and 4% of the TG level variability could be related to C16:0 and C18:0. The other clinical lipid parameters showed minor associations (R2; change=0.2%-3.5%) in both sexes.},

url = {http://hdl.handle.net/20.500.11811/4201}
}

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