Univariate and multivariate analysis of risk factors for severe clostridium difficile-associated diarrhoeaImportance of co-morbidity and serum C-reactive protein
Univariate and multivariate analysis of risk factors for severe clostridium difficile-associated diarrhoea
Importance of co-morbidity and serum C-reactive protein
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dc.contributor.advisor | Dumoulin, Franz Ludwig | |
dc.contributor.author | Hardt, Christian | |
dc.date.accessioned | 2020-04-14T14:56:12Z | |
dc.date.available | 2020-04-14T14:56:12Z | |
dc.date.issued | 08.12.2010 | |
dc.identifier.uri | https://hdl.handle.net/20.500.11811/4325 | |
dc.description.abstract | AIM: To investigate risk factors for severe clostridium difficile associated diarrhoea (CDAD) in hospitalised patients. METHODS: We analysed risk factors for severe CDAD (associated with systemic signs of hypovolemia) in 124 hospitalised patients by retrospective chart review. RESULTS: Severe CDAD was present in 27 patients (22%). Statistical analysis showed a significant association with a higher 30-d mortality (33% vs 4%, P < 0.001) and a higher proportion of longer hospital stay exceeding 14 d (74% vs 52%, P = 0.048). Charlson co-morbidity score (OR 1.29 for 1 point increment, P < 0.05) and serum C-reactive protein at diagnosis (OR 1.15 for 10 mg/L increment, P <0.001) were independent predictors of severe CDAD. CONCLUSION: Patients with a severe level of comorbidity and high serum C-reactive protein levels at the time of diagnosis should receive particular attention. | |
dc.language.iso | deu | |
dc.language.iso | eng | |
dc.rights | In Copyright | |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | |
dc.subject | Clostridium difficile | |
dc.subject | nosokomiale Diarrhoe | |
dc.subject | Komorbidität | |
dc.subject | C-reaktives Protein | |
dc.subject | 30-Tage Mortalität | |
dc.subject | Nosocomial diarrhoea | |
dc.subject | Co-morbidity | |
dc.subject | C-reactive protein | |
dc.subject | 30-day mortality | |
dc.subject.ddc | 610 Medizin, Gesundheit | |
dc.title | Univariate and multivariate analysis of risk factors for severe clostridium difficile-associated diarrhoea | |
dc.title.alternative | Importance of co-morbidity and serum C-reactive protein | |
dc.type | Dissertation oder Habilitation | |
dc.publisher.name | Universitäts- und Landesbibliothek Bonn | |
dc.publisher.location | Bonn | |
dc.rights.accessRights | openAccess | |
dc.identifier.urn | https://nbn-resolving.org/urn:nbn:de:hbz:5N-21448 | |
ulbbn.pubtype | Erstveröffentlichung | |
ulbbnediss.affiliation.name | Rheinische Friedrich-Wilhelms-Universität Bonn | |
ulbbnediss.affiliation.location | Bonn | |
ulbbnediss.thesis.level | Dissertation | |
ulbbnediss.dissID | 2144 | |
ulbbnediss.date.accepted | 10.03.2010 | |
ulbbnediss.fakultaet | Medizinische Fakultät | |
dc.contributor.coReferee | Exner, Martin |
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