Fakultäten der Universität Bonn: Suche
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Bestimmung wesentlicher Tablettenparameter mit Hilfe der Nahinfrarot-Spektroskopie
(2009-06-08)
In der vorliegenden Arbeit werden Ergebnisse von NIR-spektroskopischen Untersuchungen an Tabletten zur Porosität, Tensile Strength, dem mittleren Porenradius und der Neigung zum Deckeln vorgestellt.
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Marine-derived fungi: a source for structurally new and bioactive secondary metabolites
(2009-05-25)
The marine habitat has been proven to be a rich source for both macro- and microorganisms that produce novel and often highly bioactive natural products. Hence, the investigation of the secondary metabolite spectrum of ...
Lypd6: Ein neuartiger Modulator neuronaler nikotinischer Acetylcholinrezeptoren
(2009-05-15)
Nikotinischce Acetylcholinrezeptoren (nAChRs) zeigen für unterschiedliche Agonisten spezifische Sensitivitäten und Desensitisierungskinetiken. Diese Rezeptoreigenschaften können z.B. durch Schlangenneurotoxine oder den ...
Distinct dynamics and kinetics determine efficient antigen-presentation by LSEC and support IL-2 dependent CD8 T cell activation
(2009-05-25)
Liver sinusoidal endothelial cells (LSEC) have important clearance and immune regulatory functions, acting as unique organ resident APC. Soluble antigens are rapidly taken up by LSEC and can be cross-presented within 1h ...
Funktionelle Untersuchungen der Multidrug-Resistance-Associated Proteins (MRP) 1 und 2
(2009-12-07)
Die Multidrug-Resistenz (MDR) stellt ein ernstzunehmendes Problem in der Therapie maligner Tumore dar. Eine Ursache dieses MDR-Phänotyps ist die Überexpression von Multidrug resistance associated proteins (MRPs), insbesondere ...
The Impact of Off-Label, Compassionate and Unlicensed Use on Health Care Laws in preselected Countries
(2009-11-04)
Pressure to conduct off-label, unlicensed and compassionate use, which are hereafter summarized under the term nonlicensed drug use (NDU) is exerted onto health care professionals (HCPs) in times of situational therapeutic ...
Identification of a putative Litomosoides sigmodontis phosphate permease, Ls-ppe-1, and its role in the interaction between filarial nematodes and their Wolbachia endosymbionts & Establishment of RNA interference in the rodent filaria Litomosoides sigmodontis, a model of human filariasis
(2009-12-09)
Filariasis is a vector-borne disease that affects 200 million individuals in the tropics, a large number of them seriously, where the disease leads to blindness (onchocerciasis) or elephantiasis (lymphatic filariasis). The ...
Molekularbiologische und pharmakologische Untersuchungen zur Pathogenese der Depression und zur Wirkung von Antidepressiva
(2009-10-08)
Alle klinisch relevanten Antidepressiva entfalten ihre antidepressive Wirkung nach einer Latenzzeit von 2-6 Wochen während ihre primären pharmakologischen Effekte auf die Homöostase der Monoamine Noradrenalin (NA) und ...
Investigation of polyketide biosynthetic pathways in the sponge Theonella swinhoei and the beetle Paederus fuscipes
(2009-12-14)
Onnamides are natural products that possess strong antitumor activity and were isolated from the marine sponge Theonella swinhoei. Previous data suggested that an as-yet unculturable symbiotic bacterium living in association ......
Human Ecology of Malaria in a Rural Highland Region of South-West Kenya
(2009-12-22)
Malaria kills nearly a million people a year, uses almost half of the clinical services in Africa, and reduces economic growth by up to 1%. The immense and persistent burden of malaria makes its control one of the most ...